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Recombinant Human IL-17
点击次数：481发布时间：2013/3/29 11:56:59
更新日期：2024/8/15 17:15:29
所 在 地：美洲
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详细内容
Product Name: Human Cellexp Human Recombinant IL-17A
Alternate Name/Synonyms: CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8.
Gene Symbol: IL17A
Accession #: Q16552
Gene ID: 3605
Source: Human 293 cell expressed
Appearance: Lyophilized
Physical Form Description: Lyophilized in 10 mM Tris, pH 7.4 ａnd 250 mM NaCl.
Molecular Weight: 30 to 35 kDa, homodimer, glycosylated
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: < 1.0 EU per 1 μg of protein
Biological Activity: ED₅₀ is typically 5 to 25 ng/mL. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts.
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Storage Temp.: -80°C
Shipping: Gel pack
Background Information: Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappa B ａnd mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 ａnd cyclooxygenase-2 （PTGS2/COX-2）, as well as enhance the production of nitric oxide （NO）. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis ａnd multiple sclerosis. The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 ａnd IL-18 production ａnd enhanced the surface expression of the intracellular adhesion molecule-1 （ICAM-1） in human fibroblasts.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.
