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Recombinant Human TNF-a
点击次数：1065发布时间：2013/3/29 12:01:55
更新日期：2024/8/15 17:15:29
所 在 地：欧洲
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详细内容
Product Name: Human Cellexp Human Recombinant TNF-alpha
Alternate Name/Synonyms: TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2.
Gene Symbol: TNF
Accession #: P01375
Gene ID: 7124
Source: Human 293 cell expressed
Appearance: Lyophilized
Physical Form Description: Lyophilized in PBS.
Molecular Weight: 17 kDa, non-disulfide bonded homotrimer, glycosylated
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: < 1.0 EU per 1 μg of protein
Biological Activity: ED₅₀ is typically < 0.9 ng/mL. The specific activity was determined by the dose-dependent cytotoxity of the TNF alpha sensitive cell line L-929 in the presence of Actinomycin D.
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Storage Temp.: -80°C
Shipping: Gel pack
Background Information: Tumor Necrosis Factor-α （TNF-α） is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells ａnd certain other target cells. TNF is a cytokine involved in systemic inflammation ａnd is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis ａnd viral replication, TNF is also involved in lipid metabolism, ａnd coagulation. TNF＇s primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, ａnd cancer.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.
