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Cell Specification
The cells that make up the mammalian lens consist of two types: lens fiber cells, which form the bulk of the lens, ａnd a monolayer of epithelial cells cover the anterior surface of the fibers. The normal development of the lens of the eye involves the progressive differentiation ａnd maturation of the lens epithelial cells. As these cells migrate from the equatorial region of the lens into the interior of the lens, they produce the transparent crystallins, elongate to form lens fiber cells ａnd loose their nuclei ａnd other organelles [1]. The causes of lens epithelial cells differentiation are not well understood; however, some progress has been made in determining the underlying molecular ａnd cellular processes of lens epithelial cell differentiation. This process can be promoted by growth factors present in the ocular fluids [2]. Some growth factors such as epidermal growth factor promote mitosis; others, such as basic fibroblast growth factor, insulin growth factor, ａnd insulin promote cell migration ａnd differentiation [3].
PLEpiC from ScienCell Research Laboratories are isolated from porcine lens. PLEpiC are cryopreserved at primary culture ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. PLEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, cytokeratin-19 ａnd fibronectin. PLEpiC are negative for mycoplasma, bacteria, yeast ａnd fungi. PLEpiC are guaranteed to further expand for 5 population doublings at the condition provided by ScienCell Research Laboratories.
推荐培养基:（EpiCM, Cat. No. 4101）
产地：San Diego,US 品牌：ScienCell 储存：液氮 运输：干冰 用途：科研
