Human Cell^exp Human Recombinant IL-17A

Product Name: Human Cell^exp Human Recombinant IL-17A

Molecular Weight: 30 to 35 kDa, homodimer, glycosylated

Purity by SDS-PAGE: ≥95%

Purity by HPLC: N/A

Endotoxin Level: < 1.0 EU per 1 μg of protein

Biological Activity: ED₅₀ is typically 5 to 25 ng/mL. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Storage Temp.: -80°C

Shipping: Gel pack

Background Information: Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappa B ａnd mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 ａnd cyclooxygenase-2 （PTGS2/COX-2）, as well as enhance the production of nitric oxide （NO）. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis ａnd multiple sclerosis. The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 ａnd IL-18 production ａnd enhanced the surface expression of the intracellular adhesion molecule-1 （ICAM-1） in human fibroblasts.

Amino Acid Sequence: N/A

Handling: Centrifuge the vial prior to opening

USAGE: For Research Use Only! Not For Use in Humans.

Alternate Name/Synonyms: CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8.

Gene Symbol: IL17A

Accession #: Q16552

Gene ID: 3605

Source: Human 293 cell expressed

Appearance: Lyophilized

Physical Form Description: Lyophilized in 10 mM Tris, pH 7.4 ａnd 250 mM NaCl.