Human Cell^exp Human Recombinant IL-23

Product Name: Human Cell^exp Human Recombinant IL-23

Alternate Name/Synonyms: Interleukin 23 alpha subunit p19, Interleukin-12 subunit beta p40, SGRF, IL23P19, IL-23-A, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation, interleukin 12B （natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturation factor 2 p40）, NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF2, CLMF p40.

Gene Symbol: IL23A

Accession #: Q9NPF7

Gene ID: 51561

Source: Human 293 cell expressed

Appearance: Lyophilized

Physical Form Description: Lyophilized in PBS.

Molecular Weight: 55 kDa, heterodimer, glycosylated

Purity by SDS-PAGE: > 95%

Purity by HPLC: N/A

Endotoxin Level: < 1.0 EU per 1 μg of protein

Biological Activity: ED₅₀ is typically 2 to 20 ng/mL. The specific activity was determined by the dose-dependent secretion of h-IFN-gamma from human PBMC.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Storage Temp.: -80°C

Shipping: Gel pack

Background Information: IL23 is composed of a subunit of the heterodimeric cytokine IL23 ａnd the p40 subunit of interleukin 12 （IL12B）. Interleukin-23 （IL-23） belongs to the IL-12 family ａnd is produced by antigen presenting cells. IL-23 using IL12RB1 ａnd IL-23R （specific for IL-23） can activate STAT ａnd NF-kB pathways ａnd stimulate the production of interferon-gamma. ）. IL-23 is known to take a vital part in the inflammation process ａnd is associated with auto immune diseases. However, unlike IL12, which acts primarily on naive CD4（+） T cells, IL23 preferentially acts on memory CD4（+） T cells.

Amino Acid Sequence: N/A

Handling: Centrifuge the vial prior to opening

USAGE: For Research Use Only! Not For Use in Humans.