Human Cell^exp Human Recombinant IL-29

Product Name: Human Cell^exp Human Recombinant IL-29

Alternate Name/Synonyms: Interleukin-29, IL-29, IFN-Lambda 1, Interferon-Lambda 1, Cytokine ZCYTO21, IL29, IFNL1, ZCYTO21.

Gene Symbol: IFNL1

Accession #: Q8IU54

Gene ID: 1282618

Source: Human 293 cell expressed

Appearance: Lyophilized

Physical Form Description: Lyophilized in PBS.

Molecular Weight: 29 ａnd 35 kDa, monomer, glycosylated

Purity by SDS-PAGE: ≥95%

Purity by HPLC: N/A

Endotoxin Level: < 1.0 EU per 1 μg of protein

Biological Activity: ED₅₀ is typically 0.5 to 5 ng/mL. The specific activity was determined by the dose-dependent protection of the cytopathic effect on A549 cells （human lung adenocarcinoma epithelial cell line） that were challenged with encephalomyocarditis （EMC） virus.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Storage Temp.: -80°C

Shipping: Gel pack

Background Information: IL-29 is distantly related to type I interferons ａnd the IL-10 family. Expression of IL-29 is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor β （IL10RB） ａnd interleukin 28 receptor α. IL-29 exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity ａnd in vivo antitumor activity. IL-29 acts similarly to IFNs, but is less effective generally ａnd has activity in a more limited range of cell lines. IL-29 produced in response to viral infection, activates both monocytes ａnd macrophages producing a restricted panel of cytokines ａnd therefore is an important factor in activating innate immune responses at the site of viral infection. IFN-Lambda 1 antiviral ａnd antiproliferative activity requires Interferon-Lambda 2 receptor tyrosine residues.

Amino Acid Sequence: N/A

Handling: Centrifuge the vial prior to opening

USAGE: For Research Use Only! Not For Use in Humans.