Human Cell^exp Human Recombinant Noggin

Product Name: Human Cell^exp Human Recombinant Noggin

Alternate Name/Synonyms: SYM1, SYNS1, NOG.

Gene Symbol: NOG

Accession #: Q13253

Gene ID: 9241

Source: Human 293 cell expressed

Appearance: Lyophilized

Physical Form Description: Lyophilized in PBS.

Molecular Weight: 65 kDa, homodimer, glycosylated

Purity by SDS-PAGE: > 95%

Purity by HPLC: N/A

Endotoxin Level: < 1.0 EU per 1 μg of protein

Biological Activity: ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose-dependent inhibition of rhBMP4 induced alkaline phosphate production by ATDC5 cells.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Storage Temp.: -80°C

Shipping: Gel pack

Background Information: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family ａnd regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head ａnd other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, ａnd -14. Targeted deletion of Noggin in mice results in prenatal death ａnd recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, ａnd severe osteoporosis.

Amino Acid Sequence: N/A

Handling: Centrifuge the vial prior to opening

USAGE: For Research Use Only! Not For Use in Humans.