Recombinant Human Progranulin （Untagged）

Product Name: Recombinant Human Progranulin （Untagged）

Alternate Name/Synonyms: Proepithelin, PEPI, PC Cell-derived Growth Factor.

Gene Symbol: GRN

Accession #: P28799

Gene ID: 2896

Source: HEK 293 cells

Appearance: Liquid

Physical Form Description: 0.2 μm-filtered solution in PBS, pH 7.2.

Molecular Weight: ~65.0 kDa

Purity by SDS-PAGE: ≥95%

Purity by HPLC: N/A

Endotoxin Level: <0.1 EU/µg purified protein

Biological Activity: N/A

Reconstitution Instructions: N/A

Storage Temp.: -20°C

Shipping: Gel pack

Background Information: Progranulin （PGRN）, also called proepithelin ａnd PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair ａnd inflammation by activating signaling cascades that control cell cycle progression ａnd cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration （FTLD）. In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease （AD） ａnd potentially for MCI （Mild Cognitive Impairment）. Additionally, PGRN is described as a new ligand of TNF receptors ａnd a potential therapeutic against inflammatory disease like arthritis.

Amino Acid Sequence: Signal peptide ａnd human progranulin （aa 1-593） is untagged. Reflects the native sequence with no additional amino acids.

Handling: Centrifuge the vial prior to opening

USAGE: For Research Use Only! Not For Use in Humans.