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NVP-AEW541
点击次数：596发布时间：2013/4/3 15:49:27
更新日期：2022/8/19 17:45:40
所 在 地：美洲
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详细内容
NVP-AEW541
上海义森生物科技有限公司
技术数据:
分子量（MW）: 439.55 
化学式: C27H29N5O
溶解度: DMSO 88mg/mL Water <1mg/mL Ethanol 88mg/mL 纯度: 99% 稳定性: at -20℃ 2 years CAS号: 475489-16-8
生物活性
NVP-AEW541 is an IGF-IR inhibitor with an IC50 of median 3.6 μM.
NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative highly selective against IGF-IR, compared with the insulin receptor ａnd other tyrosine kinases. In a panel of 10 neuroblastoma cell lines positive for IGF-IR expression, NVP-AEW541 inhibited in vitro proliferation in a submicromolar/micromolar （0.4-6.8） range of concentrations. NVP-AEW541 inhibits IGF-I-mediated receptor activation ａnd downstream signaling. In addition to growth inhibition, NVP-AEW541 also induced apoptosis in vitro. Oral administration of NVP-AEW541 （50 mg/kg twice daily） inhibited tumor growth of neuroblastoma xenografts in nude mice. Therapeutic potential of NVP-AEW541 was also analyzed in Ewing’s sarcoma, osteosarcoma, rhabdomyosarcoma, ａnd pancreatic cancer. [1][2]
技术数据:
分子量（MW）: 439.55 化学式: C27H29N5O
溶解度: DMSO 88mg/mL Water <1mg/mL Ethanol 88mg/mL 纯度: 99% 稳定性: at -20℃ 2 years CAS号: 475489-16-8
生物活性
NVP-AEW541 is an IGF-IR inhibitor with an IC50 of median 3.6 μM.
NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative highly selective against IGF-IR, compared with the insulin receptor ａnd other tyrosine kinases. In a panel of 10 neuroblastoma cell lines positive for IGF-IR expression, NVP-AEW541 inhibited in vitro proliferation in a submicromolar/micromolar （0.4-6.8） range of concentrations. NVP-AEW541 inhibits IGF-I-mediated receptor activation ａnd downstream signaling. In addition to growth inhibition, NVP-AEW541 also induced apoptosis in vitro. Oral administration of NVP-AEW541 （50 mg/kg twice daily） inhibited tumor growth of neuroblastoma xenografts in nude mice. Therapeutic potential of NVP-AEW541 was also analyzed in Ewing’s sarcoma, osteosarcoma, rhabdomyosarcoma, ａnd pancreatic cancer. [1][2]
技术数据:
分子量（MW）: 439.55 化学式: C27H29N5O
溶解度: DMSO 88mg/mL Water <1mg/mL Ethanol 88mg/mL 纯度: 99% 稳定性: at -20℃ 2 years CAS号: 475489-16-8
生物活性
NVP-AEW541 is an IGF-IR inhibitor with an IC50 of median 3.6 μM.
NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative highly selective against IGF-IR, compared with the insulin receptor ａnd other tyrosine kinases. In a panel of 10 neuroblastoma cell lines positive for IGF-IR expression, NVP-AEW541 inhibited in vitro proliferation in a submicromolar/micromolar （0.4-6.8） range of concentrations. NVP-AEW541 inhibits IGF-I-mediated receptor activation ａnd downstream signaling. In addition to growth inhibition, NVP-AEW541 also induced apoptosis in vitro. Oral administration of NVP-AEW541 （50 mg/kg twice daily） inhibited tumor growth of neuroblastoma xenografts in nude mice. Therapeutic potential of NVP-AEW541 was also analyzed in Ewing’s sarcoma, osteosarcoma, rhabdomyosarcoma, ａnd pancreatic cancer. [1][2]
技术数据:
| 分子量（MW）: | 439.55 | |
|---|---|---|
| 化学式: | C27H29N5O | |
| 溶解度: | DMSO 88mg/mL Water <1mg/mL Ethanol 88mg/mL | |
| 纯度: | 99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 475489-16-8 |
生物活性
NVP-AEW541 is an IGF-IR inhibitor with an IC50 of median 3.6 μM.
NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative highly selective against IGF-IR, compared with the insulin receptor ａnd other tyrosine kinases. In a panel of 10 neuroblastoma cell lines positive for IGF-IR expression, NVP-AEW541 inhibited in vitro proliferation in a submicromolar/micromolar （0.4-6.8） range of concentrations. NVP-AEW541 inhibits IGF-I-mediated receptor activation ａnd downstream signaling. In addition to growth inhibition, NVP-AEW541 also induced apoptosis in vitro. Oral administration of NVP-AEW541 （50 mg/kg twice daily） inhibited tumor growth of neuroblastoma xenografts in nude mice. Therapeutic potential of NVP-AEW541 was also analyzed in Ewing’s sarcoma, osteosarcoma, rhabdomyosarcoma, ａnd pancreatic cancer. [1][2]
