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BS-181 HCl
点击次数：213发布时间：2013/4/7 11:44:59
更新日期：2022/8/19 17:45:40
所 在 地：美洲
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详细内容
BS-181 HCl
上海义森生物科技有限公司
技术数据:
分子量（MW）: 416.99 
化学式: C22H32N6.HCl
溶解度: DMSO 83mg/mL Water 3mg/mL Ethanol 27mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 1092443-52-1 （free base）
生物活性
BS-181 HCl is a selective cyclin-dependent kinase inhibitor with an IC50 of 21 nM for the inhibition of CDK-activating kinase. Testing of other CDKs as well as another 69 kinases showed that BS-181 HCl only inhibited CDK2 at concentrations lower than 1 μM, with CDK2 being inhibited 35-fold less potently （IC50 880 nM） than CDK7. In MCF-7 cells, BS-181 HCl inhibited the phosphorylation of CDK7 substrates, promoted cell cycle arrest ａnd apoptosis to inhibit the growth of cancer cell lines, ａnd showed antitumor effects in vivo. [1]
技术数据:
分子量（MW）: 416.99 化学式: C22H32N6.HCl
溶解度: DMSO 83mg/mL Water 3mg/mL Ethanol 27mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 1092443-52-1 （free base）
生物活性
BS-181 HCl is a selective cyclin-dependent kinase inhibitor with an IC50 of 21 nM for the inhibition of CDK-activating kinase. Testing of other CDKs as well as another 69 kinases showed that BS-181 HCl only inhibited CDK2 at concentrations lower than 1 μM, with CDK2 being inhibited 35-fold less potently （IC50 880 nM） than CDK7. In MCF-7 cells, BS-181 HCl inhibited the phosphorylation of CDK7 substrates, promoted cell cycle arrest ａnd apoptosis to inhibit the growth of cancer cell lines, ａnd showed antitumor effects in vivo. [1]
技术数据:
分子量（MW）: 416.99 化学式: C22H32N6.HCl
溶解度: DMSO 83mg/mL Water 3mg/mL Ethanol 27mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 1092443-52-1 （free base）
生物活性
BS-181 HCl is a selective cyclin-dependent kinase inhibitor with an IC50 of 21 nM for the inhibition of CDK-activating kinase. Testing of other CDKs as well as another 69 kinases showed that BS-181 HCl only inhibited CDK2 at concentrations lower than 1 μM, with CDK2 being inhibited 35-fold less potently （IC50 880 nM） than CDK7. In MCF-7 cells, BS-181 HCl inhibited the phosphorylation of CDK7 substrates, promoted cell cycle arrest ａnd apoptosis to inhibit the growth of cancer cell lines, ａnd showed antitumor effects in vivo. [1]
技术数据:
| 分子量（MW）: | 416.99 | |
|---|---|---|
| 化学式: | C22H32N6.HCl | |
| 溶解度: | DMSO 83mg/mL Water 3mg/mL Ethanol 27mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 1092443-52-1 （free base） |
生物活性
BS-181 HCl is a selective cyclin-dependent kinase inhibitor with an IC50 of 21 nM for the inhibition of CDK-activating kinase. Testing of other CDKs as well as another 69 kinases showed that BS-181 HCl only inhibited CDK2 at concentrations lower than 1 μM, with CDK2 being inhibited 35-fold less potently （IC50 880 nM） than CDK7. In MCF-7 cells, BS-181 HCl inhibited the phosphorylation of CDK7 substrates, promoted cell cycle arrest ａnd apoptosis to inhibit the growth of cancer cell lines, ａnd showed antitumor effects in vivo. [1]
