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BMS-265246
点击次数：200发布时间：2013/4/7 11:51:42
更新日期：2022/8/19 17:45:40
所 在 地：美洲
产品型号：
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详细内容
BMS-265246
上海义森生物科技有限公司
技术数据:
分子量（MW）: 345.34 
化学式: C18H17F2N3O2
溶解度: DMSO 20mg/mL Water <1mg/mL Ethanol <1mg/mL 纯度: >99% 稳定性: at -20℃ CAS号: 582315-72-8
生物活性
BMS-265246 is a potent ａnd selective CDK1/CDK2 selective inhibitor for CDK1/cycB ａnd CDK2/cycE with IC50 of 6 ａnd 9 nM, respectively. BMS-265246 inhibits the activity of CDK4/cycD with an IC50 of 0.23 μM ａnd prevents A2780 Cytox with an IC50 of 0.76μM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site ａnd forms important H-bonds with Leu83 on the protein backbone. [1] BMS-265246 exhibits CDK1 ａnd CDK2 potency that is 25- ａnd 11-fold more potent versus CDK1 ａnd CDK2, respectively. BMS-265246 represents the most potent CDK/CDK2 selective analogue from this chemotype. [1]
技术数据:
分子量（MW）: 345.34 化学式: C18H17F2N3O2
溶解度: DMSO 20mg/mL Water <1mg/mL Ethanol <1mg/mL 纯度: >99% 稳定性: at -20℃ CAS号: 582315-72-8
生物活性
BMS-265246 is a potent ａnd selective CDK1/CDK2 selective inhibitor for CDK1/cycB ａnd CDK2/cycE with IC50 of 6 ａnd 9 nM, respectively. BMS-265246 inhibits the activity of CDK4/cycD with an IC50 of 0.23 μM ａnd prevents A2780 Cytox with an IC50 of 0.76μM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site ａnd forms important H-bonds with Leu83 on the protein backbone. [1] BMS-265246 exhibits CDK1 ａnd CDK2 potency that is 25- ａnd 11-fold more potent versus CDK1 ａnd CDK2, respectively. BMS-265246 represents the most potent CDK/CDK2 selective analogue from this chemotype. [1]
技术数据:
分子量（MW）: 345.34 化学式: C18H17F2N3O2
溶解度: DMSO 20mg/mL Water <1mg/mL Ethanol <1mg/mL 纯度: >99% 稳定性: at -20℃ CAS号: 582315-72-8
生物活性
BMS-265246 is a potent ａnd selective CDK1/CDK2 selective inhibitor for CDK1/cycB ａnd CDK2/cycE with IC50 of 6 ａnd 9 nM, respectively. BMS-265246 inhibits the activity of CDK4/cycD with an IC50 of 0.23 μM ａnd prevents A2780 Cytox with an IC50 of 0.76μM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site ａnd forms important H-bonds with Leu83 on the protein backbone. [1] BMS-265246 exhibits CDK1 ａnd CDK2 potency that is 25- ａnd 11-fold more potent versus CDK1 ａnd CDK2, respectively. BMS-265246 represents the most potent CDK/CDK2 selective analogue from this chemotype. [1]
技术数据:
| 分子量（MW）: | 345.34 | |
|---|---|---|
| 化学式: | C18H17F2N3O2 | |
| 溶解度: | DMSO 20mg/mL Water <1mg/mL Ethanol <1mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ | |
| CAS号: | 582315-72-8 |
生物活性
BMS-265246 is a potent ａnd selective CDK1/CDK2 selective inhibitor for CDK1/cycB ａnd CDK2/cycE with IC50 of 6 ａnd 9 nM, respectively. BMS-265246 inhibits the activity of CDK4/cycD with an IC50 of 0.23 μM ａnd prevents A2780 Cytox with an IC50 of 0.76μM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site ａnd forms important H-bonds with Leu83 on the protein backbone. [1] BMS-265246 exhibits CDK1 ａnd CDK2 potency that is 25- ａnd 11-fold more potent versus CDK1 ａnd CDK2, respectively. BMS-265246 represents the most potent CDK/CDK2 selective analogue from this chemotype. [1]
