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Flavopiridol HCl
点击次数：198发布时间：2013/4/7 15:06:35
更新日期：2022/8/19 17:45:40
所 在 地：美洲
产品型号：
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详细内容
Flavopiridol HCl
上海义森生物科技有限公司
技术数据:
分子量（MW）: 438.3 
化学式: C21H20ClNO5.HCl
溶解度: DMSO 88mg/mL Water 88mg/mL Ethanol 9mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 131740-09-5, 146426-40-6 （free base）, 358739-41-0 （TFA）
生物活性
Flavopiridol hydrochloride is a potent cyclin-dependent kinases inhibitor with an IC50 of 100 nM. Preclinically, flavopiridol is the first cyclin-dependent kinase inhibitor. At the nanomolar concentrations, flavoporidol hydrochloride prevented rhabdoid cell growth with an IC50 ranging from 50 to 200 nM. Meanwhile, flavopiridol hydrochloride induced G1 ａnd G2 arrest ａnd apoptosis in vitro in a concentration-dependent manner. These influences were associated with the down- regulation of cyclin D1, up- modulation of p21, ａnd induction of caspase 3/7 activities. At a dose of 7.5 mg/kg, flavopiridol markedly suppress the growth of xenografted rhabdoid tumors. That was associated with the induction of p21 ａnd downregulation of cyclin D1. [1][2] Treatment of flavopiridol decreased the activities of CDK2 ａnd potently prevented cell proliferation with an IC50 ranging from 43 to 83 nM in HNSCC cells
技术数据:
分子量（MW）: 438.3 化学式: C21H20ClNO5.HCl
溶解度: DMSO 88mg/mL Water 88mg/mL Ethanol 9mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 131740-09-5, 146426-40-6 （free base）, 358739-41-0 （TFA）
生物活性
Flavopiridol hydrochloride is a potent cyclin-dependent kinases inhibitor with an IC50 of 100 nM. Preclinically, flavopiridol is the first cyclin-dependent kinase inhibitor. At the nanomolar concentrations, flavoporidol hydrochloride prevented rhabdoid cell growth with an IC50 ranging from 50 to 200 nM. Meanwhile, flavopiridol hydrochloride induced G1 ａnd G2 arrest ａnd apoptosis in vitro in a concentration-dependent manner. These influences were associated with the down- regulation of cyclin D1, up- modulation of p21, ａnd induction of caspase 3/7 activities. At a dose of 7.5 mg/kg, flavopiridol markedly suppress the growth of xenografted rhabdoid tumors. That was associated with the induction of p21 ａnd downregulation of cyclin D1. [1][2] Treatment of flavopiridol decreased the activities of CDK2 ａnd potently prevented cell proliferation with an IC50 ranging from 43 to 83 nM in HNSCC cells
技术数据:
分子量（MW）: 438.3 化学式: C21H20ClNO5.HCl
溶解度: DMSO 88mg/mL Water 88mg/mL Ethanol 9mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 131740-09-5, 146426-40-6 （free base）, 358739-41-0 （TFA）
生物活性
Flavopiridol hydrochloride is a potent cyclin-dependent kinases inhibitor with an IC50 of 100 nM. Preclinically, flavopiridol is the first cyclin-dependent kinase inhibitor. At the nanomolar concentrations, flavoporidol hydrochloride prevented rhabdoid cell growth with an IC50 ranging from 50 to 200 nM. Meanwhile, flavopiridol hydrochloride induced G1 ａnd G2 arrest ａnd apoptosis in vitro in a concentration-dependent manner. These influences were associated with the down- regulation of cyclin D1, up- modulation of p21, ａnd induction of caspase 3/7 activities. At a dose of 7.5 mg/kg, flavopiridol markedly suppress the growth of xenografted rhabdoid tumors. That was associated with the induction of p21 ａnd downregulation of cyclin D1. [1][2] Treatment of flavopiridol decreased the activities of CDK2 ａnd potently prevented cell proliferation with an IC50 ranging from 43 to 83 nM in HNSCC cells
技术数据:
| 分子量（MW）: | 438.3 | |
|---|---|---|
| 化学式: | C21H20ClNO5.HCl | |
| 溶解度: | DMSO 88mg/mL Water 88mg/mL Ethanol 9mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 131740-09-5, 146426-40-6 （free base）, 358739-41-0 （TFA） |
生物活性
Flavopiridol hydrochloride is a potent cyclin-dependent kinases inhibitor with an IC50 of 100 nM. Preclinically, flavopiridol is the first cyclin-dependent kinase inhibitor. At the nanomolar concentrations, flavoporidol hydrochloride prevented rhabdoid cell growth with an IC50 ranging from 50 to 200 nM. Meanwhile, flavopiridol hydrochloride induced G1 ａnd G2 arrest ａnd apoptosis in vitro in a concentration-dependent manner. These influences were associated with the down- regulation of cyclin D1, up- modulation of p21, ａnd induction of caspase 3/7 activities. At a dose of 7.5 mg/kg, flavopiridol markedly suppress the growth of xenografted rhabdoid tumors. That was associated with the induction of p21 ａnd downregulation of cyclin D1. [1][2] Treatment of flavopiridol decreased the activities of CDK2 ａnd potently prevented cell proliferation with an IC50 ranging from 43 to 83 nM in HNSCC cells
