产品展示
ZM-447439
点击次数：220发布时间：2013/4/7 16:59:49
更新日期：2022/8/19 17:45:40
所 在 地：美洲
产品型号：
优质供应
详细内容
ZM-447439
上海义森生物科技有限公司
技术数据:
分子量（MW）: 513.59 
化学式: C29H31N5O4
溶解度: DMSO 103mg/mL Water <1mg/mL Ethanol <1mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 331771-20-1
生物活性
ZM-447439 is a potent ａnd selective Aurora B kinase inhibitor with an IC50 of 50 nM, 1 μM ａnd 250 nM for Aurora B, A ａnd C, respectively. Other kinases such as Cdk1 ａnd PLK1 are not inhibited （up to 10 mM）. Cells treated with ZM-447439 progress through interphase, enter mitosis ａnd assemble bipolar spindles but chromosome alignment, segregation ａnd cytokinesis all fail. Mitotic Aurora kinases are essential for accurate chromosome segregation during cell division. Forced overexpression of Aurora kinase results in centrosome amplification ａnd multipolar spindles, causing aneuploidy, a hallmark of cancer. ZM447439 does not interfere with other kinases when used up to 5 µM. ZM447439 dose-dependently inhibited proliferation of all three cell lines （BON, QGP-1 ａnd MIP-101） with IC50 values in the nanomolar to low micromolar range. Moreover, aurora kinase inhibition by ZM447439 potently induced apoptosis, which was accompanied by DNA fragmentation ａnd caspase 3 ａnd 7 activation. [1][2][3]
技术数据:
分子量（MW）: 513.59 化学式: C29H31N5O4
溶解度: DMSO 103mg/mL Water <1mg/mL Ethanol <1mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 331771-20-1
生物活性
ZM-447439 is a potent ａnd selective Aurora B kinase inhibitor with an IC50 of 50 nM, 1 μM ａnd 250 nM for Aurora B, A ａnd C, respectively. Other kinases such as Cdk1 ａnd PLK1 are not inhibited （up to 10 mM）. Cells treated with ZM-447439 progress through interphase, enter mitosis ａnd assemble bipolar spindles but chromosome alignment, segregation ａnd cytokinesis all fail. Mitotic Aurora kinases are essential for accurate chromosome segregation during cell division. Forced overexpression of Aurora kinase results in centrosome amplification ａnd multipolar spindles, causing aneuploidy, a hallmark of cancer. ZM447439 does not interfere with other kinases when used up to 5 µM. ZM447439 dose-dependently inhibited proliferation of all three cell lines （BON, QGP-1 ａnd MIP-101） with IC50 values in the nanomolar to low micromolar range. Moreover, aurora kinase inhibition by ZM447439 potently induced apoptosis, which was accompanied by DNA fragmentation ａnd caspase 3 ａnd 7 activation. [1][2][3]
技术数据:
分子量（MW）: 513.59 化学式: C29H31N5O4
溶解度: DMSO 103mg/mL Water <1mg/mL Ethanol <1mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 331771-20-1
生物活性
ZM-447439 is a potent ａnd selective Aurora B kinase inhibitor with an IC50 of 50 nM, 1 μM ａnd 250 nM for Aurora B, A ａnd C, respectively. Other kinases such as Cdk1 ａnd PLK1 are not inhibited （up to 10 mM）. Cells treated with ZM-447439 progress through interphase, enter mitosis ａnd assemble bipolar spindles but chromosome alignment, segregation ａnd cytokinesis all fail. Mitotic Aurora kinases are essential for accurate chromosome segregation during cell division. Forced overexpression of Aurora kinase results in centrosome amplification ａnd multipolar spindles, causing aneuploidy, a hallmark of cancer. ZM447439 does not interfere with other kinases when used up to 5 µM. ZM447439 dose-dependently inhibited proliferation of all three cell lines （BON, QGP-1 ａnd MIP-101） with IC50 values in the nanomolar to low micromolar range. Moreover, aurora kinase inhibition by ZM447439 potently induced apoptosis, which was accompanied by DNA fragmentation ａnd caspase 3 ａnd 7 activation. [1][2][3]
技术数据:
| 分子量（MW）: | 513.59 | |
|---|---|---|
| 化学式: | C29H31N5O4 | |
| 溶解度: | DMSO 103mg/mL Water <1mg/mL Ethanol <1mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 331771-20-1 |
生物活性
ZM-447439 is a potent ａnd selective Aurora B kinase inhibitor with an IC50 of 50 nM, 1 μM ａnd 250 nM for Aurora B, A ａnd C, respectively. Other kinases such as Cdk1 ａnd PLK1 are not inhibited （up to 10 mM）. Cells treated with ZM-447439 progress through interphase, enter mitosis ａnd assemble bipolar spindles but chromosome alignment, segregation ａnd cytokinesis all fail. Mitotic Aurora kinases are essential for accurate chromosome segregation during cell division. Forced overexpression of Aurora kinase results in centrosome amplification ａnd multipolar spindles, causing aneuploidy, a hallmark of cancer. ZM447439 does not interfere with other kinases when used up to 5 µM. ZM447439 dose-dependently inhibited proliferation of all three cell lines （BON, QGP-1 ａnd MIP-101） with IC50 values in the nanomolar to low micromolar range. Moreover, aurora kinase inhibition by ZM447439 potently induced apoptosis, which was accompanied by DNA fragmentation ａnd caspase 3 ａnd 7 activation. [1][2][3]
