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AT9283
点击次数：369发布时间：2013/4/7 18:04:41
更新日期：2022/8/19 17:45:40
所 在 地：美洲
产品型号：
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详细内容
AT9283
上海义森生物科技有限公司
技术数据:
分子量（MW）: 381.43 
化学式: C19H23N7O2
溶解度: DMSO 76mg/mL Water <1mg/mL Ethanol 38mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 896466-04-9, 896466-57-2 （（±）-Lactic acid）, 896466-61-8 （HCl）, 896466-55-0 （methanesulfonate
生物活性
AT9283 is a small molecule a multi-targeted c-ABL, JAK2, Aurora A ａnd B inhibitor with of 4, 1.2, 1.1 ａnd approximate 3 nM for Bcr-Abl（T3151）, Jak2 ａnd Jak3, aurora A ａnd B, respectively. AT9283 inhibited growth ａnd survival of multiple solid tumor cell lines ａnd was efficacious in mouse xenograft models. AT9283-treatment resulted in endoreduplication ａnd ablation of serine-10 histone H3 phosphorylation in both cells ａnd tumor samples. AT9283 demonstrated in vivo efficacy in mouse xenograft models ａnd is currently under evaluation in phase I clinical trial. AT9283 showed potent antiproliferative activity on cells transformed by wild-type BCR-ABL ａnd BCR-ABL/T315I. AT9283 inhibited proliferation in a panel of BaF3 ａnd human BCR-ABL+ cell lines both sensitive ａnd resistant to imatinib because of a variety of mechanisms. In BCR-ABL+ cells, inhibition of substrates of both BCR-ABL （signal transducer ａnd activator of transcription-5） ａnd Aurora B （histone H3） at physiologically achievable concentrations was confirmed. [1][2][3]
技术数据:
分子量（MW）: 381.43 化学式: C19H23N7O2
溶解度: DMSO 76mg/mL Water <1mg/mL Ethanol 38mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 896466-04-9, 896466-57-2 （（±）-Lactic acid）, 896466-61-8 （HCl）, 896466-55-0 （methanesulfonate
生物活性
AT9283 is a small molecule a multi-targeted c-ABL, JAK2, Aurora A ａnd B inhibitor with of 4, 1.2, 1.1 ａnd approximate 3 nM for Bcr-Abl（T3151）, Jak2 ａnd Jak3, aurora A ａnd B, respectively. AT9283 inhibited growth ａnd survival of multiple solid tumor cell lines ａnd was efficacious in mouse xenograft models. AT9283-treatment resulted in endoreduplication ａnd ablation of serine-10 histone H3 phosphorylation in both cells ａnd tumor samples. AT9283 demonstrated in vivo efficacy in mouse xenograft models ａnd is currently under evaluation in phase I clinical trial. AT9283 showed potent antiproliferative activity on cells transformed by wild-type BCR-ABL ａnd BCR-ABL/T315I. AT9283 inhibited proliferation in a panel of BaF3 ａnd human BCR-ABL+ cell lines both sensitive ａnd resistant to imatinib because of a variety of mechanisms. In BCR-ABL+ cells, inhibition of substrates of both BCR-ABL （signal transducer ａnd activator of transcription-5） ａnd Aurora B （histone H3） at physiologically achievable concentrations was confirmed. [1][2][3]
技术数据:
分子量（MW）: 381.43 化学式: C19H23N7O2
溶解度: DMSO 76mg/mL Water <1mg/mL Ethanol 38mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 896466-04-9, 896466-57-2 （（±）-Lactic acid）, 896466-61-8 （HCl）, 896466-55-0 （methanesulfonate
生物活性
AT9283 is a small molecule a multi-targeted c-ABL, JAK2, Aurora A ａnd B inhibitor with of 4, 1.2, 1.1 ａnd approximate 3 nM for Bcr-Abl（T3151）, Jak2 ａnd Jak3, aurora A ａnd B, respectively. AT9283 inhibited growth ａnd survival of multiple solid tumor cell lines ａnd was efficacious in mouse xenograft models. AT9283-treatment resulted in endoreduplication ａnd ablation of serine-10 histone H3 phosphorylation in both cells ａnd tumor samples. AT9283 demonstrated in vivo efficacy in mouse xenograft models ａnd is currently under evaluation in phase I clinical trial. AT9283 showed potent antiproliferative activity on cells transformed by wild-type BCR-ABL ａnd BCR-ABL/T315I. AT9283 inhibited proliferation in a panel of BaF3 ａnd human BCR-ABL+ cell lines both sensitive ａnd resistant to imatinib because of a variety of mechanisms. In BCR-ABL+ cells, inhibition of substrates of both BCR-ABL （signal transducer ａnd activator of transcription-5） ａnd Aurora B （histone H3） at physiologically achievable concentrations was confirmed. [1][2][3]
技术数据:
| 分子量（MW）: | 381.43 | |
|---|---|---|
| 化学式: | C19H23N7O2 | |
| 溶解度: | DMSO 76mg/mL Water <1mg/mL Ethanol 38mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 896466-04-9, 896466-57-2 （（±）-Lactic acid）, 896466-61-8 （HCl）, 896466-55-0 （methanesulfonate |
生物活性
AT9283 is a small molecule a multi-targeted c-ABL, JAK2, Aurora A ａnd B inhibitor with of 4, 1.2, 1.1 ａnd approximate 3 nM for Bcr-Abl（T3151）, Jak2 ａnd Jak3, aurora A ａnd B, respectively. AT9283 inhibited growth ａnd survival of multiple solid tumor cell lines ａnd was efficacious in mouse xenograft models. AT9283-treatment resulted in endoreduplication ａnd ablation of serine-10 histone H3 phosphorylation in both cells ａnd tumor samples. AT9283 demonstrated in vivo efficacy in mouse xenograft models ａnd is currently under evaluation in phase I clinical trial. AT9283 showed potent antiproliferative activity on cells transformed by wild-type BCR-ABL ａnd BCR-ABL/T315I. AT9283 inhibited proliferation in a panel of BaF3 ａnd human BCR-ABL+ cell lines both sensitive ａnd resistant to imatinib because of a variety of mechanisms. In BCR-ABL+ cells, inhibition of substrates of both BCR-ABL （signal transducer ａnd activator of transcription-5） ａnd Aurora B （histone H3） at physiologically achievable concentrations was confirmed. [1][2][3]
