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H 89 2HCl
点击次数：157发布时间：2013/4/8 15:10:08
更新日期：2022/8/19 17:45:40
所 在 地：美洲
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详细内容
H 89 2HCl
上海义森生物科技有限公司
技术数据:
分子量（MW）: 519.28 
化学式: C20H20BrN3O2S.2HCl
溶解度: DMSO 104mg/mL Water 6mg/mL Ethanol <1mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 130964-39-5, 127243-85-0 （free base）
生物活性
H 89 dihydrochloride is a protein kinase A inhibitor that also inhibits several other kinases with IC50 of 80, 120, 135, 270, 2600 ａnd 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα ａnd MAPKAP-K1b, respectively. It is a potent ａnd selective inhibitor of PKA, with an IC50 of about 50 nM. [1] It also inhibits PKG ａnd the µ isotype of PKC （at about 500 nM）. In contrast, most other PKC isotypes are much more weakly inhibited, with IC50’s in the 32 µM range. [2]
技术数据:
分子量（MW）: 519.28 化学式: C20H20BrN3O2S.2HCl
溶解度: DMSO 104mg/mL Water 6mg/mL Ethanol <1mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 130964-39-5, 127243-85-0 （free base）
生物活性
H 89 dihydrochloride is a protein kinase A inhibitor that also inhibits several other kinases with IC50 of 80, 120, 135, 270, 2600 ａnd 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα ａnd MAPKAP-K1b, respectively. It is a potent ａnd selective inhibitor of PKA, with an IC50 of about 50 nM. [1] It also inhibits PKG ａnd the µ isotype of PKC （at about 500 nM）. In contrast, most other PKC isotypes are much more weakly inhibited, with IC50’s in the 32 µM range. [2]
技术数据:
分子量（MW）: 519.28 化学式: C20H20BrN3O2S.2HCl
溶解度: DMSO 104mg/mL Water 6mg/mL Ethanol <1mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 130964-39-5, 127243-85-0 （free base）
生物活性
H 89 dihydrochloride is a protein kinase A inhibitor that also inhibits several other kinases with IC50 of 80, 120, 135, 270, 2600 ａnd 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα ａnd MAPKAP-K1b, respectively. It is a potent ａnd selective inhibitor of PKA, with an IC50 of about 50 nM. [1] It also inhibits PKG ａnd the µ isotype of PKC （at about 500 nM）. In contrast, most other PKC isotypes are much more weakly inhibited, with IC50’s in the 32 µM range. [2]
技术数据:
| 分子量（MW）: | 519.28 | |
|---|---|---|
| 化学式: | C20H20BrN3O2S.2HCl | |
| 溶解度: | DMSO 104mg/mL Water 6mg/mL Ethanol <1mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 130964-39-5, 127243-85-0 （free base） |
生物活性
H 89 dihydrochloride is a protein kinase A inhibitor that also inhibits several other kinases with IC50 of 80, 120, 135, 270, 2600 ａnd 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα ａnd MAPKAP-K1b, respectively. It is a potent ａnd selective inhibitor of PKA, with an IC50 of about 50 nM. [1] It also inhibits PKG ａnd the µ isotype of PKC （at about 500 nM）. In contrast, most other PKC isotypes are much more weakly inhibited, with IC50’s in the 32 µM range. [2]
