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人滑膜细胞
上海义森生物科技有限公司
人滑膜细胞呈成纤维细胞状,是健康的滑膜组织中主要的细胞类型。滑膜细胞形成被称为滑膜衬里层的特殊结构。电子显微镜下可观察到内层中细胞与细胞间广泛地接触。滑膜细胞产生润滑液成分,并且与关节腔的吸收和血液/润滑液交换有关。滑膜细胞增生,表现为不依赖于支持物生长,并且分泌大量的效应分子来促进炎症和关节损坏,同时,它们自身也是自分泌和旁分泌网络中效应因子的一部分。滑膜细胞表达钙粘蛋白-11,这为研究滑膜组织的组成和形态提供了新的线索,同时也是重要的治疗目标。 人滑膜细胞提取于人滑膜组织,原代冻存。每管含有细胞数>5×105 cells/ml,此细胞通过CD90和Fibronectin免疫荧光染色验证,经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。
推荐培养基:(SM, Cat. No. 4701)
产地:San Diego,US储存:液氮
品牌:ScienCell
运输:干冰
用途:科研
Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. The Synoviocytes form a distinct structure called the synovial lining layer. Electron microscopy revealed extensive cell-to-cell contacts within the lining layer [1]. The Synoviocytes produce synovial fluid components and are responsible for absorption from the joint cavity, and for blood/synovial fluid exchanges. The synoviocytes proliferate, show anchorage-independent growth, and also secrete a variety of effector molecules that promote inflammation and joint destruction and, themselves are part of a complex network of autocrine and paracrine acting factors. The synoviocytes express cadherin-11 providing new insight into synovial tissue organization and morphogenesis [2] and of interest as a therapeutic target.
HS from ScienCell Research Laboratories are isolated from human synovium. HS are cryopreserved at passage one cultures and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HS are characterized by their fibroblast-like morphology, growth pattern and immunocytochemistry of CD 90 and fibronectin. HS are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HS are guaranteed for 15 population doublings at the conditions provided by ScienCell Research Laboratories.
Reference
[1]. Barland, P., Novikoff, A.B., Hamerman, D. (1962) Electron microscopy of the human synovial membrane. J Cell Biol. 14:207-220.
[2]. Kiener , H. P. and Brenner, M. B. (2005) Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion. Arthritis Res Ther. 7(2): 49-54.
人滑膜细胞呈成纤维细胞状,是健康的滑膜组织中主要的细胞类型。滑膜细胞形成被称为滑膜衬里层的特殊结构。电子显微镜下可观察到内层中细胞与细胞间广泛地接触。滑膜细胞产生润滑液成分,并且与关节腔的吸收和血液/润滑液交换有关。滑膜细胞增生,表现为不依赖于支持物生长,并且分泌大量的效应分子来促进炎症和关节损坏,同时,它们自身也是自分泌和旁分泌网络中效应因子的一部分。滑膜细胞表达钙粘蛋白-11,这为研究滑膜组织的组成和形态提供了新的线索,同时也是重要的治疗目标。 人滑膜细胞提取于人滑膜组织,原代冻存。每管含有细胞数>5×105 cells/ml,此细胞通过CD90和Fibronectin免疫荧光染色验证,经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。
推荐培养基:(SM, Cat. No. 4701)
产地:San Diego,US储存:液氮
品牌:ScienCell
运输:干冰
用途:科研
Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. The Synoviocytes form a distinct structure called the synovial lining layer. Electron microscopy revealed extensive cell-to-cell contacts within the lining layer [1]. The Synoviocytes produce synovial fluid components and are responsible for absorption from the joint cavity, and for blood/synovial fluid exchanges. The synoviocytes proliferate, show anchorage-independent growth, and also secrete a variety of effector molecules that promote inflammation and joint destruction and, themselves are part of a complex network of autocrine and paracrine acting factors. The synoviocytes express cadherin-11 providing new insight into synovial tissue organization and morphogenesis [2] and of interest as a therapeutic target.
HS from ScienCell Research Laboratories are isolated from human synovium. HS are cryopreserved at passage one cultures and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HS are characterized by their fibroblast-like morphology, growth pattern and immunocytochemistry of CD 90 and fibronectin. HS are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HS are guaranteed for 15 population doublings at the conditions provided by ScienCell Research Laboratories.
Reference
[1]. Barland, P., Novikoff, A.B., Hamerman, D. (1962) Electron microscopy of the human synovial membrane. J Cell Biol. 14:207-220.
[2]. Kiener , H. P. and Brenner, M. B. (2005) Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion. Arthritis Res Ther. 7(2): 49-54.
推荐培养基:(SM, Cat. No. 4701)
产地:San Diego,US储存:液氮
品牌:ScienCell
运输:干冰
用途:科研
Human synoviocytes (HS), the predominant cell type of healthy synovial tissue, are fibroblast-like cells. The Synoviocytes form a distinct structure called the synovial lining layer. Electron microscopy revealed extensive cell-to-cell contacts within the lining layer [1]. The Synoviocytes produce synovial fluid components and are responsible for absorption from the joint cavity, and for blood/synovial fluid exchanges. The synoviocytes proliferate, show anchorage-independent growth, and also secrete a variety of effector molecules that promote inflammation and joint destruction and, themselves are part of a complex network of autocrine and paracrine acting factors. The synoviocytes express cadherin-11 providing new insight into synovial tissue organization and morphogenesis [2] and of interest as a therapeutic target.
HS from ScienCell Research Laboratories are isolated from human synovium. HS are cryopreserved at passage one cultures and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HS are characterized by their fibroblast-like morphology, growth pattern and immunocytochemistry of CD 90 and fibronectin. HS are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HS are guaranteed for 15 population doublings at the conditions provided by ScienCell Research Laboratories.
Reference
[1]. Barland, P., Novikoff, A.B., Hamerman, D. (1962) Electron microscopy of the human synovial membrane. J Cell Biol. 14:207-220.
[2]. Kiener , H. P. and Brenner, M. B. (2005) Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion. Arthritis Res Ther. 7(2): 49-54.