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人肝窦内皮细胞
上海义森生物科技有限公司
内皮细胞具有多种生理功能，并且是许多病理过程的中心环节。肝脏含有两种不同类型的内皮细胞：血管内皮细胞和肝窦内皮细胞。肝窦内皮细胞是具有类似树突状细胞特殊表型的微血管内皮细胞，并能作为CD4+-T细胞的抗原呈递细胞。因此，肝窦内皮细胞表现为一种新型的器官定植 “非专业”抗原呈递细胞，在肝脏局部免疫调控和诱导免疫耐受中发挥作用。肝脏的微环境系统，如门静脉系统成分和来自肝窦细胞的可溶性介质，严密的控制着SEC的抗原呈递作用，以避免出现由免疫介导的损伤。SEC表达特征性的表面受体，并且在形态和代谢上与大血管内皮细胞明显不同。有报道显示在肝再生过程中，SEC是能对环境区域刺激做出快速的局部的反应孔隙的动态调节器。由于SEC在肝窦中的重要位置，使得SEC机能异常和结构改变将会对整个肝脏造成广泛的影响。
推荐培养基:（ECM, Cat. No. 1001）
产地：San Diego,US储存：液氮
品牌：ScienCell
运输：干冰
用途：科研
Endothelial cells play multiple physiological functions ａnd are central to many pathological processes. The liver contains two distinct endothelial cell types: vascular ａnd sinusoidal. Sinusoidal endothelial cells （SEC） are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells ａnd a unique function as antigen-presenting cells for CD4+ T cells. Thus, SEC represent a new type of organ-resident "non-professional" antigen-presenting cell that appears to be involved in the local control of the immune response ａnd the induction of immune tolerance in the liver [1]. The hepatic microenvironment, i.e. portal venous constituents ａnd soluble mediators from sinusoidal cell populations, tightly control antigen presentation by SEC to avoid immune-mediated damage. SEC express well-characterized surface receptors ａnd differ morphologically ａnd metabolically from large-vessel endothelia [3]. It has reported that SEC are dynamic regulators of porosity that respond rapidly ａnd locally to environmental zonal stimuli during liver regeneration [2]. Due to its strategic position in the liver sinusoid, SEC dysfunction ａnd structural alterations have far-reaching repercussions for the whole liver.
HHSEC from ScienCell Research Laboratories are isolated from human liver. HHSEC are cryopreserved immediately after purification ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HHSEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII ａnd P-CAM （CD-31）. HHSEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HHSEC are guaranteed to further expand for 15 population doublings in the conditions provided by ScienCell Research Laboratories.
Reference
[1] Limmer A, Knolle PA. （2001） Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell. Arch Immunol Ther Exp （Warsz） 49 Suppl 1:S7-11.
[2]. Wack KE, Ross MA, Zegarra V, Sysko LR, Watkins SC, Stolz DB. （2001） Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver. Hepatology 33（2）:363-78.
[3]. Gervaz P, Scholl B, Mainguene C, Poitry S, Gillet M, Wexner S. （2000） Angiogenesis of liver metastases: role of sinusoidal endothelial cells. Dis Colon Rectum 43（7）:980-6.
内皮细胞具有多种生理功能，并且是许多病理过程的中心环节。肝脏含有两种不同类型的内皮细胞：血管内皮细胞和肝窦内皮细胞。肝窦内皮细胞是具有类似树突状细胞特殊表型的微血管内皮细胞，并能作为CD4+-T细胞的抗原呈递细胞。因此，肝窦内皮细胞表现为一种新型的器官定植 “非专业”抗原呈递细胞，在肝脏局部免疫调控和诱导免疫耐受中发挥作用。肝脏的微环境系统，如门静脉系统成分和来自肝窦细胞的可溶性介质，严密的控制着SEC的抗原呈递作用，以避免出现由免疫介导的损伤。SEC表达特征性的表面受体，并且在形态和代谢上与大血管内皮细胞明显不同。有报道显示在肝再生过程中，SEC是能对环境区域刺激做出快速的局部的反应孔隙的动态调节器。由于SEC在肝窦中的重要位置，使得SEC机能异常和结构改变将会对整个肝脏造成广泛的影响。
推荐培养基:（ECM, Cat. No. 1001）
产地：San Diego,US储存：液氮
品牌：ScienCell
运输：干冰
用途：科研
Endothelial cells play multiple physiological functions ａnd are central to many pathological processes. The liver contains two distinct endothelial cell types: vascular ａnd sinusoidal. Sinusoidal endothelial cells （SEC） are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells ａnd a unique function as antigen-presenting cells for CD4+ T cells. Thus, SEC represent a new type of organ-resident "non-professional" antigen-presenting cell that appears to be involved in the local control of the immune response ａnd the induction of immune tolerance in the liver [1]. The hepatic microenvironment, i.e. portal venous constituents ａnd soluble mediators from sinusoidal cell populations, tightly control antigen presentation by SEC to avoid immune-mediated damage. SEC express well-characterized surface receptors ａnd differ morphologically ａnd metabolically from large-vessel endothelia [3]. It has reported that SEC are dynamic regulators of porosity that respond rapidly ａnd locally to environmental zonal stimuli during liver regeneration [2]. Due to its strategic position in the liver sinusoid, SEC dysfunction ａnd structural alterations have far-reaching repercussions for the whole liver.
HHSEC from ScienCell Research Laboratories are isolated from human liver. HHSEC are cryopreserved immediately after purification ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HHSEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII ａnd P-CAM （CD-31）. HHSEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HHSEC are guaranteed to further expand for 15 population doublings in the conditions provided by ScienCell Research Laboratories.
Reference
[1] Limmer A, Knolle PA. （2001） Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell. Arch Immunol Ther Exp （Warsz） 49 Suppl 1:S7-11.
[2]. Wack KE, Ross MA, Zegarra V, Sysko LR, Watkins SC, Stolz DB. （2001） Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver. Hepatology 33（2）:363-78.
[3]. Gervaz P, Scholl B, Mainguene C, Poitry S, Gillet M, Wexner S. （2000） Angiogenesis of liver metastases: role of sinusoidal endothelial cells. Dis Colon Rectum 43（7）:980-6.
推荐培养基:（ECM, Cat. No. 1001）
产地：San Diego,US储存：液氮
品牌：ScienCell
运输：干冰
用途：科研
Endothelial cells play multiple physiological functions ａnd are central to many pathological processes. The liver contains two distinct endothelial cell types: vascular ａnd sinusoidal. Sinusoidal endothelial cells （SEC） are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells ａnd a unique function as antigen-presenting cells for CD4+ T cells. Thus, SEC represent a new type of organ-resident "non-professional" antigen-presenting cell that appears to be involved in the local control of the immune response ａnd the induction of immune tolerance in the liver [1]. The hepatic microenvironment, i.e. portal venous constituents ａnd soluble mediators from sinusoidal cell populations, tightly control antigen presentation by SEC to avoid immune-mediated damage. SEC express well-characterized surface receptors ａnd differ morphologically ａnd metabolically from large-vessel endothelia [3]. It has reported that SEC are dynamic regulators of porosity that respond rapidly ａnd locally to environmental zonal stimuli during liver regeneration [2]. Due to its strategic position in the liver sinusoid, SEC dysfunction ａnd structural alterations have far-reaching repercussions for the whole liver.
HHSEC from ScienCell Research Laboratories are isolated from human liver. HHSEC are cryopreserved immediately after purification ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HHSEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII ａnd P-CAM （CD-31）. HHSEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HHSEC are guaranteed to further expand for 15 population doublings in the conditions provided by ScienCell Research Laboratories.
Reference
[1] Limmer A, Knolle PA. （2001） Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell. Arch Immunol Ther Exp （Warsz） 49 Suppl 1:S7-11.
[2]. Wack KE, Ross MA, Zegarra V, Sysko LR, Watkins SC, Stolz DB. （2001） Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver. Hepatology 33（2）:363-78.
[3]. Gervaz P, Scholl B, Mainguene C, Poitry S, Gillet M, Wexner S. （2000） Angiogenesis of liver metastases: role of sinusoidal endothelial cells. Dis Colon Rectum 43（7）:980-6.
