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人骨骼肌细胞
上海义森生物科技有限公司
骨骼肌细胞是人体内的细胞。它们是成肌细胞融合形成的多核细胞。骨骼肌再生是有许多因素参与的复杂过程。当骨骼肌受损时，静止的、被称为卫星细胞的成肌细胞被激活增殖、迁移、*终分化。多种的细胞信号途径，包括磷脂酰肌醇（-3）激酶、钙神经素、JAK2/STAT3和有丝分裂原活化蛋白激酶，参与骨骼肌的生长。在体外培养的人类骨骼肌细胞中进行的骨骼肌分化实验发现胰岛素刺激的葡萄糖转运是葡萄糖转运蛋白4介导的，硫酸乙酰肝素蛋白聚糖也与此过程有关。单核细胞融合形成多核肌管是骨骼肌发育的中心事件。该过程的发生和进展中，成肌细胞控制着一系列复杂的交互活动。骨骼肌细胞的培养是研究细胞分化中该过程的重要模型。
推荐培养基:（SkMCM, Cat. No. 3501）
产地：San Diego,US储存：液氮
品牌：ScienCell
运输：干冰
用途：科研
Skeletal muscle cells are one of the largest cells in the body. They are multinucleate formed by the fusion of myoblasts. Skeletal muscle regeneration is a complex process in which many factors are involved. When skeletal muscle suffers an injury, quiescent resident myoblasts called satellite cells are activated to proliferate, migrate, ａnd finally differentiate [1]. Various cellular signaling pathways, such as phosphatidylinositol 3-kinase, calcineurin, Janus kinase 2/signal transducer ａnd activator of transcription 3 （STAT3）, ａnd mitogen-activated protein kinase （MAPK） have been suggested to play an important role in skeletal muscle growth [2]. Insulin-stimulated glucose transport in cultured human skeletal muscle is mediated by GLUT4 ａnd heparan sulfate proteoglycan is involved in skeletal muscle differentiation [3]. The fusion of mononucleatcd cells to form multinucleated myotubes is a central event in skeletal muscle development. Controlling the onset ａnd progression of this process is a complex set of interactions between myoblasts ａnd their environment. Skeletal muscle cell culture is a useful model for studying this process of cell differentiation.
HSkMC from ScienCell Research Laboratories are isolated from human skeletal muscle of the pectoral girdle. HSkMC are cryopreserved on primary culture ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HSkMC are characterized by immunofluorescent method with antibodies to myosin, actin ａnd actinin. HSkMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HSkMC are guaranteed to further expand for 15 population doublings at the conditions provided by ScienCell Research Laboratories.
Reference
[1]. Villena, J., Brandan, E. （2004） Dermatan sulfate exerts an enhanced growth factor response on skeletal muscle satellite cell proliferation ａnd migration. J Cell Physiol. 198（2）:169-78.
[2]. Morris, R. T., Spangenburg, E. E., Booth, F. W. （2004） Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle. J Appl Physiol. 96（1）:398-404.
[3]. Al-Khalili, L., Chibalin, A. V., Kannisto, K., Zhang, B. B., Permert, J., Holman, G. D., Ehrenborg, E., Ding, V. D., Zierath, J. R., Krook, A. （2004） Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 ａnd GLUT1 content. Cell Mol Life Sci. 60（5）:991-8.
骨骼肌细胞是人体内的细胞。它们是成肌细胞融合形成的多核细胞。骨骼肌再生是有许多因素参与的复杂过程。当骨骼肌受损时，静止的、被称为卫星细胞的成肌细胞被激活增殖、迁移、*终分化。多种的细胞信号途径，包括磷脂酰肌醇（-3）激酶、钙神经素、JAK2/STAT3和有丝分裂原活化蛋白激酶，参与骨骼肌的生长。在体外培养的人类骨骼肌细胞中进行的骨骼肌分化实验发现胰岛素刺激的葡萄糖转运是葡萄糖转运蛋白4介导的，硫酸乙酰肝素蛋白聚糖也与此过程有关。单核细胞融合形成多核肌管是骨骼肌发育的中心事件。该过程的发生和进展中，成肌细胞控制着一系列复杂的交互活动。骨骼肌细胞的培养是研究细胞分化中该过程的重要模型。
推荐培养基:（SkMCM, Cat. No. 3501）
产地：San Diego,US储存：液氮
品牌：ScienCell
运输：干冰
用途：科研
Skeletal muscle cells are one of the largest cells in the body. They are multinucleate formed by the fusion of myoblasts. Skeletal muscle regeneration is a complex process in which many factors are involved. When skeletal muscle suffers an injury, quiescent resident myoblasts called satellite cells are activated to proliferate, migrate, ａnd finally differentiate [1]. Various cellular signaling pathways, such as phosphatidylinositol 3-kinase, calcineurin, Janus kinase 2/signal transducer ａnd activator of transcription 3 （STAT3）, ａnd mitogen-activated protein kinase （MAPK） have been suggested to play an important role in skeletal muscle growth [2]. Insulin-stimulated glucose transport in cultured human skeletal muscle is mediated by GLUT4 ａnd heparan sulfate proteoglycan is involved in skeletal muscle differentiation [3]. The fusion of mononucleatcd cells to form multinucleated myotubes is a central event in skeletal muscle development. Controlling the onset ａnd progression of this process is a complex set of interactions between myoblasts ａnd their environment. Skeletal muscle cell culture is a useful model for studying this process of cell differentiation.
HSkMC from ScienCell Research Laboratories are isolated from human skeletal muscle of the pectoral girdle. HSkMC are cryopreserved on primary culture ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HSkMC are characterized by immunofluorescent method with antibodies to myosin, actin ａnd actinin. HSkMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HSkMC are guaranteed to further expand for 15 population doublings at the conditions provided by ScienCell Research Laboratories.
Reference
[1]. Villena, J., Brandan, E. （2004） Dermatan sulfate exerts an enhanced growth factor response on skeletal muscle satellite cell proliferation ａnd migration. J Cell Physiol. 198（2）:169-78.
[2]. Morris, R. T., Spangenburg, E. E., Booth, F. W. （2004） Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle. J Appl Physiol. 96（1）:398-404.
[3]. Al-Khalili, L., Chibalin, A. V., Kannisto, K., Zhang, B. B., Permert, J., Holman, G. D., Ehrenborg, E., Ding, V. D., Zierath, J. R., Krook, A. （2004） Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 ａnd GLUT1 content. Cell Mol Life Sci. 60（5）:991-8.
推荐培养基:（SkMCM, Cat. No. 3501）
产地：San Diego,US储存：液氮
品牌：ScienCell
运输：干冰
用途：科研
Skeletal muscle cells are one of the largest cells in the body. They are multinucleate formed by the fusion of myoblasts. Skeletal muscle regeneration is a complex process in which many factors are involved. When skeletal muscle suffers an injury, quiescent resident myoblasts called satellite cells are activated to proliferate, migrate, ａnd finally differentiate [1]. Various cellular signaling pathways, such as phosphatidylinositol 3-kinase, calcineurin, Janus kinase 2/signal transducer ａnd activator of transcription 3 （STAT3）, ａnd mitogen-activated protein kinase （MAPK） have been suggested to play an important role in skeletal muscle growth [2]. Insulin-stimulated glucose transport in cultured human skeletal muscle is mediated by GLUT4 ａnd heparan sulfate proteoglycan is involved in skeletal muscle differentiation [3]. The fusion of mononucleatcd cells to form multinucleated myotubes is a central event in skeletal muscle development. Controlling the onset ａnd progression of this process is a complex set of interactions between myoblasts ａnd their environment. Skeletal muscle cell culture is a useful model for studying this process of cell differentiation.
HSkMC from ScienCell Research Laboratories are isolated from human skeletal muscle of the pectoral girdle. HSkMC are cryopreserved on primary culture ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HSkMC are characterized by immunofluorescent method with antibodies to myosin, actin ａnd actinin. HSkMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HSkMC are guaranteed to further expand for 15 population doublings at the conditions provided by ScienCell Research Laboratories.
Reference
[1]. Villena, J., Brandan, E. （2004） Dermatan sulfate exerts an enhanced growth factor response on skeletal muscle satellite cell proliferation ａnd migration. J Cell Physiol. 198（2）:169-78.
[2]. Morris, R. T., Spangenburg, E. E., Booth, F. W. （2004） Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle. J Appl Physiol. 96（1）:398-404.
[3]. Al-Khalili, L., Chibalin, A. V., Kannisto, K., Zhang, B. B., Permert, J., Holman, G. D., Ehrenborg, E., Ding, V. D., Zierath, J. R., Krook, A. （2004） Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 ａnd GLUT1 content. Cell Mol Life Sci. 60（5）:991-8.
