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大鼠雪旺细胞
上海义森生物科技有限公司
雪旺细胞是神经嵴的衍生物，包盖周围神经形成轴突的髓鞘。它们环绕在末梢神经轴突的轴上，沿着轴突节形成一层髓磷脂髓鞘。雪旺细胞对末梢神经的发育，功能和再生起着重要作用。当轴突快死亡时，雪旺细胞环绕其周围帮助消化轴突。连续的雪旺细胞形成一个空的管道，在其尾端形成新的轴突。在末梢神经中雪旺细胞的数量是受到严格调控的。体外增殖受到诸如PDGF，FGF，神经元和其它多肽类生长因子的刺激.雪旺细胞提供相对简单，明确，易懂的哺乳动物模型以用来研究一系列发育问题。在研究神经病和神经再生，以及中枢神经系统修复方面雪旺细胞也具有特殊的临床重要性。
大鼠雪旺细胞（RA）提取于大鼠坐骨神经组织，代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过对S-100, GFAP和CD90的免疫荧光染色验证，经测试不含有支原体、细菌、酵母和真菌。细胞可以达到10倍增。
推荐培养基:（SCM, Cat. No. 1701）
储存：液氮
运输：干冰
用途：科研
Schwann cells are neural crest derivatives that ensheathe ａnd myelinate axons of peripheral nerves [1]. They wrap individually around the shaft of peripheral axons, forming a layer or myelin sheath along segments of the axon. Schwann cells play important roles in the development, function ａnd regeneration of peripheral nerves. When an axon is dying, the Schwann cells surrounding it aid in its digestion. This leaves an empty channel formed by successive Schwann cells, through which a new axon may grow from a severed end. The number of Schwann cells in peripheral nerve is tightly regulated [2]. Their proliferation in vitro can be stimulated by polypeptide growth factors including PDGF, FGF, neuregulin ａnd others [3]. The Schwann cells provide a relatively simple, well-defined ａnd accessible mammalian model for the study of a number of developmental questions. It is also of particular clinical importance to understand the biology of Schwann cells, not only in the context of neuropathies ａnd nerve regeneration, but also because the cells or their precursor might be especially well suited as implants to facilitate repair in the CNS.
RSC from ScienCell Research Laboratories are isolated from rat sciatic nerves. RSC are cryopreserved at passage one ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. RSC are characterized by immunofluorescent method with antibodies to S-100, GFAP ａnd CD90. RSC are negative for mycoplasma, bacteria, yeast ａnd fungi. RSC are guaranteed to further expand for 10 population doublings in the conditions provided by ScienCell Research Laboratories.
Reference
[1] Jessen, K. R. ａnd Mirsky, R. （1999） Schwann cells ａnd their precursors emerge as major regulators of nerve development. Trends Neurosci. 22:402-410.
[2] Syroid, D. E., Maycox, P. R., Burrola, P. G., Liu, N., Wen, D., Lee, K. F., Lemke, G., Kilpatrick, T. J. （1996） Cell death in the Schwann cell lineage ａnd its regulation by neuregulin. Proc. Natl. Acad. Sci. USA 93:9229-9234.
[3] Rahmatullah, M., Schroering, A., Rothblum, K., Stahl, R. C., Urban, B ａnd Carey, D. J. （1998） Synergistic regulation of Schwann cells proliferation by heregulin ａnd forskolin. Mol. Cell. Biol. 18:6245-6252.
雪旺细胞是神经嵴的衍生物，包盖周围神经形成轴突的髓鞘。它们环绕在末梢神经轴突的轴上，沿着轴突节形成一层髓磷脂髓鞘。雪旺细胞对末梢神经的发育，功能和再生起着重要作用。当轴突快死亡时，雪旺细胞环绕其周围帮助消化轴突。连续的雪旺细胞形成一个空的管道，在其尾端形成新的轴突。在末梢神经中雪旺细胞的数量是受到严格调控的。体外增殖受到诸如PDGF，FGF，神经元和其它多肽类生长因子的刺激.雪旺细胞提供相对简单，明确，易懂的哺乳动物模型以用来研究一系列发育问题。在研究神经病和神经再生，以及中枢神经系统修复方面雪旺细胞也具有特殊的临床重要性。
大鼠雪旺细胞（RA）提取于大鼠坐骨神经组织，代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过对S-100, GFAP和CD90的免疫荧光染色验证，经测试不含有支原体、细菌、酵母和真菌。细胞可以达到10倍增。
推荐培养基:（SCM, Cat. No. 1701）
储存：液氮
运输：干冰
用途：科研
Schwann cells are neural crest derivatives that ensheathe ａnd myelinate axons of peripheral nerves [1]. They wrap individually around the shaft of peripheral axons, forming a layer or myelin sheath along segments of the axon. Schwann cells play important roles in the development, function ａnd regeneration of peripheral nerves. When an axon is dying, the Schwann cells surrounding it aid in its digestion. This leaves an empty channel formed by successive Schwann cells, through which a new axon may grow from a severed end. The number of Schwann cells in peripheral nerve is tightly regulated [2]. Their proliferation in vitro can be stimulated by polypeptide growth factors including PDGF, FGF, neuregulin ａnd others [3]. The Schwann cells provide a relatively simple, well-defined ａnd accessible mammalian model for the study of a number of developmental questions. It is also of particular clinical importance to understand the biology of Schwann cells, not only in the context of neuropathies ａnd nerve regeneration, but also because the cells or their precursor might be especially well suited as implants to facilitate repair in the CNS.
RSC from ScienCell Research Laboratories are isolated from rat sciatic nerves. RSC are cryopreserved at passage one ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. RSC are characterized by immunofluorescent method with antibodies to S-100, GFAP ａnd CD90. RSC are negative for mycoplasma, bacteria, yeast ａnd fungi. RSC are guaranteed to further expand for 10 population doublings in the conditions provided by ScienCell Research Laboratories.
Reference
[1] Jessen, K. R. ａnd Mirsky, R. （1999） Schwann cells ａnd their precursors emerge as major regulators of nerve development. Trends Neurosci. 22:402-410.
[2] Syroid, D. E., Maycox, P. R., Burrola, P. G., Liu, N., Wen, D., Lee, K. F., Lemke, G., Kilpatrick, T. J. （1996） Cell death in the Schwann cell lineage ａnd its regulation by neuregulin. Proc. Natl. Acad. Sci. USA 93:9229-9234.
[3] Rahmatullah, M., Schroering, A., Rothblum, K., Stahl, R. C., Urban, B ａnd Carey, D. J. （1998） Synergistic regulation of Schwann cells proliferation by heregulin ａnd forskolin. Mol. Cell. Biol. 18:6245-6252.
大鼠雪旺细胞（RA）提取于大鼠坐骨神经组织，代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过对S-100, GFAP和CD90的免疫荧光染色验证，经测试不含有支原体、细菌、酵母和真菌。细胞可以达到10倍增。
推荐培养基:（SCM, Cat. No. 1701）
储存：液氮
运输：干冰
用途：科研
Schwann cells are neural crest derivatives that ensheathe ａnd myelinate axons of peripheral nerves [1]. They wrap individually around the shaft of peripheral axons, forming a layer or myelin sheath along segments of the axon. Schwann cells play important roles in the development, function ａnd regeneration of peripheral nerves. When an axon is dying, the Schwann cells surrounding it aid in its digestion. This leaves an empty channel formed by successive Schwann cells, through which a new axon may grow from a severed end. The number of Schwann cells in peripheral nerve is tightly regulated [2]. Their proliferation in vitro can be stimulated by polypeptide growth factors including PDGF, FGF, neuregulin ａnd others [3]. The Schwann cells provide a relatively simple, well-defined ａnd accessible mammalian model for the study of a number of developmental questions. It is also of particular clinical importance to understand the biology of Schwann cells, not only in the context of neuropathies ａnd nerve regeneration, but also because the cells or their precursor might be especially well suited as implants to facilitate repair in the CNS.
RSC from ScienCell Research Laboratories are isolated from rat sciatic nerves. RSC are cryopreserved at passage one ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. RSC are characterized by immunofluorescent method with antibodies to S-100, GFAP ａnd CD90. RSC are negative for mycoplasma, bacteria, yeast ａnd fungi. RSC are guaranteed to further expand for 10 population doublings in the conditions provided by ScienCell Research Laboratories.
Reference
[1] Jessen, K. R. ａnd Mirsky, R. （1999） Schwann cells ａnd their precursors emerge as major regulators of nerve development. Trends Neurosci. 22:402-410.
[2] Syroid, D. E., Maycox, P. R., Burrola, P. G., Liu, N., Wen, D., Lee, K. F., Lemke, G., Kilpatrick, T. J. （1996） Cell death in the Schwann cell lineage ａnd its regulation by neuregulin. Proc. Natl. Acad. Sci. USA 93:9229-9234.
[3] Rahmatullah, M., Schroering, A., Rothblum, K., Stahl, R. C., Urban, B ａnd Carey, D. J. （1998） Synergistic regulation of Schwann cells proliferation by heregulin ａnd forskolin. Mol. Cell. Biol. 18:6245-6252.
