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| 大鼠小胶质细胞 |
上海义森生物科技有限公司
小胶质细胞是中枢神经系统中一种胶质细胞类型，它是神经胶质细胞网不可或缺的重要组成部分。小胶质细胞在大脑实质从早期向成熟阶段发育的过程中被发现。在大脑发育过程中或中枢神经系统受损或受到病理伤害而发生程序性细胞死亡时，小胶质细胞的作用如同大脑中的巨噬细胞。小胶质细胞被认为是大脑免疫监督的主要细胞，向CD4阳性T细胞表达的II类MHC呈递抗原，具有Fc-介导的巨噬作用并与造血和巨噬细胞组织有许多同样的抗原。另外，有大量证据表明作用，在大脑中小胶质细胞通过与神经元和其它胶质细胞共同作用和产生诸如生长因子、细胞因子和其它因子的方式来参与许多生理和病理过程。
推荐培养基:（MM, Cat. No. 1901）
储存：液氮
运输：干冰
用途：科研
Microglia, one of the glial cell types in the CNS, are an important integral component of neuro-glial cell network [1]. They have been observed in the brain parenchyma from the early stage of development to the mature state. Microglia act as brain macrophages when programmed cell death occurs during brain development or when the CNS is injured or pathologically damaged. Microglia can be considered as the main cell in brain immune surveillance, can present antigens in the molecular context of MHC class II expression to CD-4 positive T cells, are capable of Fc-mediated phagocytosis, ａnd share many common antigens with hemopoietic ａnd tissue macrophages [2]. Furthermore, there is accumulating evidence that microglia are involved in a variety of physiological ａnd pathological processes in the brain by interacting with neurons ａnd other glial cells ａnd through production of biologically active substances such as growth factors, cytokines, ａnd other factors [3].
RM from ScienCell Research Laboratories are isolated from primary rat brain cell culture. Cryopreserved RM are frozen after purification without further expansion ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. RM culture in different size of vessels is about 90% confluent ａnd delivered in gel ice. RM is characterized by immunofluorescent method with antibody to OX-42 （CD 11b/c）. RM is negative mycoplasma, bacteria, yeast ａnd fungi. RM is guaranteed to further culture in the condition provided by ScienCell Research Laboratories.
Reference
[1] Lee, S. C., Liu, W., Brosnan, C. F. ａnd Dickson, D. W. （1992） Characterization of primary human fetal dissociated central nervous system cultures with an emphasis on microgia. Laboratory Investigation. 67:465-476.
[2] Fedoroff, S., Zhai, R. ａnd Novak, J. P. （1997） Microglia ａnd astroglia have a common progenitor cell. J. Neurosci. Res. 50: 477-486.
[3] Stoll, G. ａnd Jander, S. （1999） The role of microglia ａnd macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 58:233-247.
小胶质细胞是中枢神经系统中一种胶质细胞类型，它是神经胶质细胞网不可或缺的重要组成部分。小胶质细胞在大脑实质从早期向成熟阶段发育的过程中被发现。在大脑发育过程中或中枢神经系统受损或受到病理伤害而发生程序性细胞死亡时，小胶质细胞的作用如同大脑中的巨噬细胞。小胶质细胞被认为是大脑免疫监督的主要细胞，向CD4阳性T细胞表达的II类MHC呈递抗原，具有Fc-介导的巨噬作用并与造血和巨噬细胞组织有许多同样的抗原。另外，有大量证据表明作用，在大脑中小胶质细胞通过与神经元和其它胶质细胞共同作用和产生诸如生长因子、细胞因子和其它因子的方式来参与许多生理和病理过程。
推荐培养基:（MM, Cat. No. 1901）
储存：液氮
运输：干冰
用途：科研
Microglia, one of the glial cell types in the CNS, are an important integral component of neuro-glial cell network [1]. They have been observed in the brain parenchyma from the early stage of development to the mature state. Microglia act as brain macrophages when programmed cell death occurs during brain development or when the CNS is injured or pathologically damaged. Microglia can be considered as the main cell in brain immune surveillance, can present antigens in the molecular context of MHC class II expression to CD-4 positive T cells, are capable of Fc-mediated phagocytosis, ａnd share many common antigens with hemopoietic ａnd tissue macrophages [2]. Furthermore, there is accumulating evidence that microglia are involved in a variety of physiological ａnd pathological processes in the brain by interacting with neurons ａnd other glial cells ａnd through production of biologically active substances such as growth factors, cytokines, ａnd other factors [3].
RM from ScienCell Research Laboratories are isolated from primary rat brain cell culture. Cryopreserved RM are frozen after purification without further expansion ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. RM culture in different size of vessels is about 90% confluent ａnd delivered in gel ice. RM is characterized by immunofluorescent method with antibody to OX-42 （CD 11b/c）. RM is negative mycoplasma, bacteria, yeast ａnd fungi. RM is guaranteed to further culture in the condition provided by ScienCell Research Laboratories.
Reference
[1] Lee, S. C., Liu, W., Brosnan, C. F. ａnd Dickson, D. W. （1992） Characterization of primary human fetal dissociated central nervous system cultures with an emphasis on microgia. Laboratory Investigation. 67:465-476.
[2] Fedoroff, S., Zhai, R. ａnd Novak, J. P. （1997） Microglia ａnd astroglia have a common progenitor cell. J. Neurosci. Res. 50: 477-486.
[3] Stoll, G. ａnd Jander, S. （1999） The role of microglia ａnd macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 58:233-247.
推荐培养基:（MM, Cat. No. 1901）
储存：液氮
运输：干冰
用途：科研
Microglia, one of the glial cell types in the CNS, are an important integral component of neuro-glial cell network [1]. They have been observed in the brain parenchyma from the early stage of development to the mature state. Microglia act as brain macrophages when programmed cell death occurs during brain development or when the CNS is injured or pathologically damaged. Microglia can be considered as the main cell in brain immune surveillance, can present antigens in the molecular context of MHC class II expression to CD-4 positive T cells, are capable of Fc-mediated phagocytosis, ａnd share many common antigens with hemopoietic ａnd tissue macrophages [2]. Furthermore, there is accumulating evidence that microglia are involved in a variety of physiological ａnd pathological processes in the brain by interacting with neurons ａnd other glial cells ａnd through production of biologically active substances such as growth factors, cytokines, ａnd other factors [3].
RM from ScienCell Research Laboratories are isolated from primary rat brain cell culture. Cryopreserved RM are frozen after purification without further expansion ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. RM culture in different size of vessels is about 90% confluent ａnd delivered in gel ice. RM is characterized by immunofluorescent method with antibody to OX-42 （CD 11b/c）. RM is negative mycoplasma, bacteria, yeast ａnd fungi. RM is guaranteed to further culture in the condition provided by ScienCell Research Laboratories.
Reference
[1] Lee, S. C., Liu, W., Brosnan, C. F. ａnd Dickson, D. W. （1992） Characterization of primary human fetal dissociated central nervous system cultures with an emphasis on microgia. Laboratory Investigation. 67:465-476.
[2] Fedoroff, S., Zhai, R. ａnd Novak, J. P. （1997） Microglia ａnd astroglia have a common progenitor cell. J. Neurosci. Res. 50: 477-486.
[3] Stoll, G. ａnd Jander, S. （1999） The role of microglia ａnd macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 58:233-247.
