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大鼠心肌细胞
上海义森生物科技有限公司
心肌细胞是机体上*具有活力的细胞。它的收缩是肌源性的，其活动与神经刺激无关。所有的心肌细胞都能自发的、有节律的进行细胞膜的去极化和复极化。心肌细胞占有心脏重量的75%，约为心脏细胞数量的1/3。它们是具有高氧含量及含有大量线粒体的一类细胞。分化的心肌细胞几乎无增生能力，在肾上腺素经过Ras/MEK途径的刺激下，细胞表现为肥大。心力衰竭时心肌细胞肥大和凋亡时心脏的收缩功能下降。心肌细胞有着复杂的信号网络，调控心脏泵功能的节律性。该信号网络是研究心肌细胞死亡的细胞信号调控机理的有效模型。
推荐培养基:（CMM, Cat. No. 6201）
储存：液氮
运输：干冰
用途：科研
The cardiac myocyte is the most physically energetic cell in the body. Its contraction is myogenic, i.e. it is independent of nervous stimulation. All cardiac myocyte are capable of spontaneous rhythmic depolarization ａnd repolarization of their membrane. Cardiac myocytes occupy as much as 75% of cardiac mass but constitute only about one third of the total cell number in the heart. They are highly specialized high-oxygen-content cells ａnd house a large number of mitochondria [1]. Differentiated cardiac myocytes have little capacity to proliferate ａnd show the hypertrophic growth in response to alpha1-adrenergic stimuli via the Ras/MEK pathway [2]. Cardiac myocyte hypertrophy ａnd apoptosis have been implicated in the loss of contractile function during heart failure. Cardiac myocytes have a complex network of signals that regulates their essential role in the rhythmic pumping of the heart [3]. This network is an appealing model system in which to study the basic principles of cellular signaling mechanisms leading to cardiac myocyte death.
RCM from ScienCell Research Laboratories are isolated from rat heart. RCM are cryopreserved on primary cultures ａnd delivered frozen. Each vial contains >1 x 106 cells in 1 ml volume. RCM are characterized by immunofluorescent method with antibody to myosin. RCM are negative for mycoplasma, bacteria, yeast ａnd fungi. RCM are guaranteed to further culture at the condition provided by ScienCell Research Laboratories.
Reference
[1] Bodyak, N., Kang, P. M., Hiromura, M., Sulijoadikusumo, I., Horikoshi, N., Khrapko, K. ａnd Usheva, A. （2004） Gene expression profiling of the aging mouse cardiac myocytes. Nucleic Acids Research 30（17）:3788-3794.
[2] Tamamori-Adachi, M., Ito, H., Nobori, K., Hayashida, K., Kawauchi, J., Adachi, S., Ikeda, M. A. ａnd Kitajima, S. （2004） Expression of cyclin D1 ａnd CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy. Biochem Biophys Res Commun 296（2）:274-80.
[3] Sambrano, G.R., Fraser, I., Han, H., Ni, Y., O＇Connell, T., Yan, Z. ａnd Stull, J. T. （2004） Navigating the signaling network in mouse cardiac myocytes. Nature 420（6916）:712-4.
心肌细胞是机体上*具有活力的细胞。它的收缩是肌源性的，其活动与神经刺激无关。所有的心肌细胞都能自发的、有节律的进行细胞膜的去极化和复极化。心肌细胞占有心脏重量的75%，约为心脏细胞数量的1/3。它们是具有高氧含量及含有大量线粒体的一类细胞。分化的心肌细胞几乎无增生能力，在肾上腺素经过Ras/MEK途径的刺激下，细胞表现为肥大。心力衰竭时心肌细胞肥大和凋亡时心脏的收缩功能下降。心肌细胞有着复杂的信号网络，调控心脏泵功能的节律性。该信号网络是研究心肌细胞死亡的细胞信号调控机理的有效模型。
推荐培养基:（CMM, Cat. No. 6201）
储存：液氮
运输：干冰
用途：科研
The cardiac myocyte is the most physically energetic cell in the body. Its contraction is myogenic, i.e. it is independent of nervous stimulation. All cardiac myocyte are capable of spontaneous rhythmic depolarization ａnd repolarization of their membrane. Cardiac myocytes occupy as much as 75% of cardiac mass but constitute only about one third of the total cell number in the heart. They are highly specialized high-oxygen-content cells ａnd house a large number of mitochondria [1]. Differentiated cardiac myocytes have little capacity to proliferate ａnd show the hypertrophic growth in response to alpha1-adrenergic stimuli via the Ras/MEK pathway [2]. Cardiac myocyte hypertrophy ａnd apoptosis have been implicated in the loss of contractile function during heart failure. Cardiac myocytes have a complex network of signals that regulates their essential role in the rhythmic pumping of the heart [3]. This network is an appealing model system in which to study the basic principles of cellular signaling mechanisms leading to cardiac myocyte death.
RCM from ScienCell Research Laboratories are isolated from rat heart. RCM are cryopreserved on primary cultures ａnd delivered frozen. Each vial contains >1 x 106 cells in 1 ml volume. RCM are characterized by immunofluorescent method with antibody to myosin. RCM are negative for mycoplasma, bacteria, yeast ａnd fungi. RCM are guaranteed to further culture at the condition provided by ScienCell Research Laboratories.
Reference
[1] Bodyak, N., Kang, P. M., Hiromura, M., Sulijoadikusumo, I., Horikoshi, N., Khrapko, K. ａnd Usheva, A. （2004） Gene expression profiling of the aging mouse cardiac myocytes. Nucleic Acids Research 30（17）:3788-3794.
[2] Tamamori-Adachi, M., Ito, H., Nobori, K., Hayashida, K., Kawauchi, J., Adachi, S., Ikeda, M. A. ａnd Kitajima, S. （2004） Expression of cyclin D1 ａnd CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy. Biochem Biophys Res Commun 296（2）:274-80.
[3] Sambrano, G.R., Fraser, I., Han, H., Ni, Y., O＇Connell, T., Yan, Z. ａnd Stull, J. T. （2004） Navigating the signaling network in mouse cardiac myocytes. Nature 420（6916）:712-4.
推荐培养基:（CMM, Cat. No. 6201）
储存：液氮
运输：干冰
用途：科研
The cardiac myocyte is the most physically energetic cell in the body. Its contraction is myogenic, i.e. it is independent of nervous stimulation. All cardiac myocyte are capable of spontaneous rhythmic depolarization ａnd repolarization of their membrane. Cardiac myocytes occupy as much as 75% of cardiac mass but constitute only about one third of the total cell number in the heart. They are highly specialized high-oxygen-content cells ａnd house a large number of mitochondria [1]. Differentiated cardiac myocytes have little capacity to proliferate ａnd show the hypertrophic growth in response to alpha1-adrenergic stimuli via the Ras/MEK pathway [2]. Cardiac myocyte hypertrophy ａnd apoptosis have been implicated in the loss of contractile function during heart failure. Cardiac myocytes have a complex network of signals that regulates their essential role in the rhythmic pumping of the heart [3]. This network is an appealing model system in which to study the basic principles of cellular signaling mechanisms leading to cardiac myocyte death.
RCM from ScienCell Research Laboratories are isolated from rat heart. RCM are cryopreserved on primary cultures ａnd delivered frozen. Each vial contains >1 x 106 cells in 1 ml volume. RCM are characterized by immunofluorescent method with antibody to myosin. RCM are negative for mycoplasma, bacteria, yeast ａnd fungi. RCM are guaranteed to further culture at the condition provided by ScienCell Research Laboratories.
Reference
[1] Bodyak, N., Kang, P. M., Hiromura, M., Sulijoadikusumo, I., Horikoshi, N., Khrapko, K. ａnd Usheva, A. （2004） Gene expression profiling of the aging mouse cardiac myocytes. Nucleic Acids Research 30（17）:3788-3794.
[2] Tamamori-Adachi, M., Ito, H., Nobori, K., Hayashida, K., Kawauchi, J., Adachi, S., Ikeda, M. A. ａnd Kitajima, S. （2004） Expression of cyclin D1 ａnd CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy. Biochem Biophys Res Commun 296（2）:274-80.
[3] Sambrano, G.R., Fraser, I., Han, H., Ni, Y., O＇Connell, T., Yan, Z. ａnd Stull, J. T. （2004） Navigating the signaling network in mouse cardiac myocytes. Nature 420（6916）:712-4.
