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Recombinant Human IL-4仅用于研究 不适用于诊断或治疗
Recombinant Human IL-4
产品编号:
200-04
别名:
BCGF,BCDF,B cell stimulating factor （BSF-1）
描述:
IL-4 is a pleiotropic cytokine that regulates diverse T ａnd B cell responses including cell proliferation, survival ａnd gene expression. Produced by mast cells, T cells ａnd bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, ａnd IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 ａnd IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production ａnd allergy. Recombinant human IL-4 is a 14.9 kDa globular protein containing 129 amino acid residues.
氨基酸序列:
MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
研究领域:
 | 细胞凋亡 |  | 癌症 |
 | 细胞培养 |  | 免疫系统 |
 | 炎症 |  | 增殖 |
 | 干细胞及分化 |  | 过敏 |
 | 移植 |
原产国:
USA
仅用于研究。不适用于诊断或治疗。
原创作者：北京雅安达生物技术有限公司
