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原装进口Recombinant Murine β-NGF 高品质 450-34
点击次数:283发布时间:2013/9/9 16:13:14
更新日期:2022/12/30 11:21:23
所 在 地:中国大陆
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原装进口Recombinant Murine β-NGF 高品质 450-34 现货 产品订购说明:库存现货、当天发货、现价折扣、优惠促销.为广大客户提供高质量细胞因子和生命科学相关产品。质量可靠,被全国各大院校科研机构认可并指定为elisa试剂盒 标准品对照品 长期供应商。并提供实验代测服务,我们将以专业执着,精益求精的精神服务于广大科研用户。
Recombinant Murine β-NGF 高品质 450-34 现货 根据细胞因子主要的功能不同分类
1.干扰素(interferon, IFN) 1957年发现的细胞因子,*初发现某一种病毒感染的细胞能产生一种物质可干扰另一种病毒的感染和复制,因此而得名。根据干扰素产生的来源和结构不同,可分为IFN-α、IFN-β和IFN-γ,他们分别由白细胞、成纤维细胞和活化T细胞所产生。各种不同的IFN生物学活性基本相同,具有抗病毒、抗肿瘤和免疫调节等作用。
2.肿瘤坏死因子(tumor necrosis factor, TNF) 根据其产生来源和结构不同,可分为TNF-α和TNF-β两类,前者由单核-巨噬细胞产生,后者由活化T细胞产生,又名淋巴毒素(lymphotoxin, LT)。两类TNF基本的生物学活性相似,除具有杀伤肿瘤细胞外,还有免疫调节、参与发热和炎症的发生。大剂量TNF-α可引起恶液质,因而TNF-α又称恶液质素(cachectin)。
胞因子的作用特点:多效性 、重叠性 、协同性 、拮抗性和双重性。
Catalog Number: 450-34
Synonyms:
Description: β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of murine β-NGF is a noncovalently disulfide-linked homodimer, of two 13.4 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
AA Sequence: MSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G
Source: E.coli
Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Cross Reactivity: Human, Mouse
Research Interests: Angiogenesis/ Cardiovascular Chemotaxis
Diabetes / Weight Regulation Inflammation
Neurobiology Stem Cells & Differentiation
Wound Healing
Country of Origin: USA