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*新价格450-34 Recombinant Murine β-NGF 细胞因子
点击次数：231发布时间：2013/9/10 16:19:42
更新日期：2022/12/30 11:21:23
所 在 地：中国大陆
产品型号：
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详细内容
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Recombinant Murine β-NGF
Catalog Number:
450-34
Synonyms:
Description:
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 ａnd NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, ａnd plays a crucial role in the development ａnd preservation of the sensory ａnd sympathetic nervous systems. β-NGF also acts as a growth ａnd differentiation factor for B lymphocytes ａnd enhances B-cell survival. The functional form of murine β-NGF is a noncovalently disulfide-linked homodimer, of two 13.4 kDa polypeptide monomers （240 total amino acid residues）. The three disulfide bonds are required for biological activity.
AA Sequence:
MSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Cross Reactivity:
Human, Mouse
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