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Recombinant Murine VEGF
Catalog Number:
450-32
Synonyms:
Vascular Endothelial Growth Factor, VPF, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen
Description:
VEGF is a potent growth ａnd angiogenic cytokine. It stimulates proliferation ａnd survival of endothelial cells, ａnd promotes angiogenesis ａnd vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal ａnd pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis ａnd intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase （flt-1）, KDR gene product （the murine homolog of KDR is the flk-1 gene product） ａnd the flt4 gene product. Recombinant murine VEGF is a 39.0 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
AA Sequence:
MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
Biological Activity:
Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells （HUVEC） using a concentration range of 1.0-5.0 ng/ml.
Cross Reactivity:
Chicken, Human, Rabbit, Rat, Mouse, Insect
Research Interests:
 | Angiogenesis/ Cardiovascular |  | Cancer |
 | Inflammation |  | Proliferation |
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.
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