简单介绍：Recombinant Human IL-16 produced in E. coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 13.4 kDa.
IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells ａnd CD4+ monocytes ａnd eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) ａnd MHC class II molecules on CD4+ T cells. Human ａnd murine IL-16 show significant cross-species reactivity.
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