产品名称 钙离子ATP酶通道蛋白抗体
产品缩写 ATP2C1
蛋 白 名 Calcium-transporting ATPase type 2C member 1
别 称 HHD; BCPM; PMR1; SPCA1; hSPCA1; ATP2C1A
来 源 小鼠
特 异 性 抗人,猴
分 子 量 100kDa
克隆类型 单克隆抗体：IgG1；克隆号：4G12
应 用 WB免疫印迹；ELISA
成 分 Ascitic fluid containing 0.03% sodium azide.
免 疫 原 Purified recombinant fragment of ATP2C1 expressed in E. Coli.
保存条件 连续使用时4°C存储，保质期六个月；长期存储时建议分装为10ul以上小包装-20°C存储，并避免反复冻融，保质期一年。
背景资料 ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also
designated SPLA in rat), also regulates the transport of calcium in the Golgi
complex ａnd is related to other P-type ATPases family members, such as the
sarco(endo)plasmic calcium ATPase (SERCA) ａnd the plasma membrane calcium
ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two
splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters ａnd erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
