产品名称 程序性死亡配体1抗体
产品缩写 PDL1/CD274
蛋 白 名 Programmed cell death 1 ligand 1
别 称 B7-H,B7H1,PDL1,PD-L1,PDCD1L1,PDCD1LG1
免 疫 原 重组蛋白（来源于大肠杆菌）
来 源 兔
特 异 性 抗人
克隆类型 多克隆
应 用 WB免疫印迹
成 分 200μg/ml亲和纯化抗体，0.01M PBS，30%甘油。
保存条件 连续使用时4°C存储，保质期六个月；长期存储时建议分装为10ul以上小包装-20°C存储，并避免反复冻融，保质期一年。
背景资料 CD274(CD274 molecule), also known as PDCD1L1, PDL1, B7H1, CD274 molecule, cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), Programmed cell death 1 ligand 1, is a protein that in humans is encoded by the CD274 gene. Levels of B7H1 correlated with PTEN loss in glioblastoma specimens, ａnd tumor-specific T cells lysed human glioma targets expressing wildtype PTEN more effectively than those expressing mutant PTEN. Sequence analysis predicted that it has 290-amino acid. immunoresistance in glioma is related to loss of the tumor suppressor PTEN ａnd is mediated in part by B7H1.Programmed death ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease ａnd other disease states such as hepatitis. Using microarray analysis ａnd flow cytometry, Barber et al.(2006) found that Pd1 was highly upregulated by functionally exhausted CD8 T cells from mice infected with a lymphocytic choriomeningitis virus (LCMV) strain causing chronic infection, but not by functional memory CD8 T cells from mice infected with an LCMV strain causing acute infection.
