产品名称 Bcl-xL蛋白抗体
产品缩写 BCL2L1/Bcl-X/S
蛋 白 名 Bcl-2-like protein 1
别 称 BCLX,BCL2L,BCLXL,BCLXS,Bcl-X,bcl-xL,bcl-xS,PPP1R52,BCL-XL/S
免 疫 原 多肽
来 源 兔
特 异 性 抗人、大鼠、小鼠
克隆类型 多克隆
应 用 IH(P)免疫组化(石蜡);IH(F)免疫组化(冰冻);IC细胞免疫化学;WB免疫印迹
成 分 200μg/ml亲和纯化抗体,0.01M PBS,30%甘油。
保存条件 连续使用时4°C存储,保质期六个月;长期存储时建议分装为10ul以上小包装-20°C存储,并避免反复冻融,保质期一年。
背景资料 The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.