产品名称 乳腺癌易感基因1抗体（小鼠 大鼠）
产品缩写 BRCA1
蛋 白 名 Breast cancer type 1 susceptibility protein
别 称 IRIS,PSCP,BRCAI,BRCC1,PNCA4,RNF53,BROVCA1,PPP1R53
免 疫 原 重组蛋白（来源于大肠杆菌）
来 源 兔
特 异 性 抗人、大鼠、小鼠
克隆类型 多克隆
应 用 IH(P)免疫组化(石蜡)；IH(F)免疫组化(冰冻)；IC细胞免疫化学；WB免疫印迹
成 分 200μg/ml亲和纯化抗体，0.01M PBS，30%甘油。
保存条件 连续使用时4°C存储，保质期六个月；长期存储时建议分装为10ul以上小包装-20°C存储，并避免反复冻融，保质期一年。
背景资料 This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, ａnd it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, ａnd signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, ａnd through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, ａnd recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers ａnd more than 80% of inherited breast ａnd ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization ａnd physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
