促肾上腺皮质激素ACTH(18-39)抗体

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【别    名】Adrenocorticotropic hormone; Adrenocorticotropin; Adrenocorticotropin Hormone; Alpha Melanocyte Stimulating Hormone; Beta Lipotropin; Beta Melanocyte Stimulating Hormone; CLIP; Corticotropin; Corticotropin Like Intermediary Peptide; Corticotropin lipotropin precursor; Lipotropin Beta; Lipotropin Gamma; LPH; Melanotropin Alpha; Met Enkephalin; MSH; NPP; POC; POMC; Pro opiomelanocortin; Proopiomelanocortin; COLI_HUMAN.

【规   格】0.1ml：0.2ml    

【研究域】肿瘤  神经生物学  信号转导  生长因子和激素  内分泌病  

【抗体来源】Rabbit

【克隆类型】Polyclonal

【交叉反应】Human, 

【产品应用】ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.
促肾上腺皮质激素ACTH(18-39)抗体

【分 子 量】2.5/4.5kDa

【性    状】冻干或液体

【浓    度】1mg/1ml

【免 疫 原】KLH conjugated synthetic peptide derived from human ACTH(18-39)

【亚    型】IgG

【纯化方法】亲和纯化的蛋白

【储 存 液】储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol.

【笃玛 贮   存说明】-20°C的一年。避免重复冻结/解冻周期。冻干抗体稳定在室温下至少一个月,超过一年保持在-20°C。重组在无菌pH值7.4 - 0.01 m PBS或稀释的抗体抗体稳定至少两周2 - 4°C。

促肾上腺皮质激素ACTH(18-39)抗体产品介绍  

background:

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type ａnd the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis ａnd the maintenance of normal adrenal weight, ａnd lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, ａnd epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain ａnd energy homeostasis, melanocyte stimulation, ａnd immune modulation. These include several distinct melanotropins, lipotropins, ａnd endorphins that are contained within the adrenocorticotrophin ａnd beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, ａnd red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

 

Function:

ACTH stimulates the adrenal glands to release cortisol. 

MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. 

Beta-endorphin ａnd Met-enkephalin are endogenous opiates. 

 

Subcellular Location:

Secreted.

 

Tissue Specificity:

ACTH ａnd MSH are produced by the pituitary gland.

 

Post-translational modifications:

Specific enzymatic cleavages at paired basic residues yield the different active peptides. 

O-glycosylated; reducing sugar is probably N-acetylgalactosamine. 

 

DISEASE:

Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal ａnd physical requirements, as the result of excessive accumulation of body fat. 

Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency ａnd red hair. 

 

Similarity:

Belongs to the POMC family.

 

 

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