TRC丨艾美捷TRC a，a-二甲基-4-说明书

艾美捷TRC a，a-二甲基-4-化学性质：

Catalogue NumberD474700

Chemical Namea,a-Dimethyl-4-[(methylamino)methyl]-2-thiazolemethanol Hydrochloride

Alternate CAS #Free Base: 1051463-24-1

Molecular FormulaC₈H₁₅ClN₂OS

AppearanceDark Brown Gel to Light Brown Solid

Molecular Weight222.74

Storage-20°C, Inert atmosphere, Light sensitive

SolubilityChloroform, DMSO, Methanol

CategoryStandards; Pharmaceutical/API Drug Impurities/Metabolites;

ApplicationsA Cobicistat (C633150) impurity. Cobicistat is a HIV protease inhibitor ａnd have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.

ReferencesVon, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);

目录编号D474700

化学名称a，a-二甲基-4-[（甲氨基）甲基]-2-噻唑甲醇盐酸盐

备用CAS自由基：1051463-24-1

分子式C₈H₁₅ClN公司₂操作系统

外观深棕色凝胶至浅棕色固体

分子量222.74

储存-20°C，惰性气氛，光敏

溶解度氯丨仿、DMSO、甲醇

类别标准；药物/原料药药物杂质/代谢物；

参考文献Von，H.，Exp.Rev.Clin。药理学。，5, 557 (2012); Lepist，E.I.等人：抗微生物。代理人Chemother。，56, 5409 (2012); Orr，S.T.M.等人：《医学化学杂志》。，55, 4896 (2012);

艾美捷TRC a，a-二甲基-4-相关研究：

(2＇S)-Nicotine 1-Oxide-d4

rac-Nicotine 1-Oxide-d4

1,1-Dimethyl-4-phenylpiperazinium Iodide

1,3-Dioleoylglycerol-d5

Diphenyl Terephthalate

2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

Dimethyl 2,2＇-((2-(2-(2-(Bis(2-methoxy-2-oxoethyl)amino)-5-(chlorocarbonyl)phenoxy)ethoxy)-4-methylphenyl)azanediyl)diacetate

2-(2,4-Dichlorophenyl)thiazole-4-carboxylic Acid

4,5-Dimethylnicotinonitrile

2,5-Dichloro-4-methylpyrimidine

TRC拥有多域的化学业技术，包括碳水化合物，芳香烃，硝化物，硫化物以及放射同位素和稳定同位素标记化合物，各类标准品等。艾美捷科技是TRC的中国代理商，为科研工作者提供优质的产品与服务。

来源：https://www.amyjet.com/brand/Toronto-Research-Chemicals.shtml