中英文说明丨艾美捷Aniracetam阿尼西坦

Aniracetam is a nootropic ampakine that exhibits anxiolytic ａnd neuroprotective activities. Aniracetam acts as a positive allosteric modulator of AMPA receptors, slowing receptor deactivation; it also acts on D2 receptors, 5-HT2A receptors, ａnd nicotinic acetylcholine receptors (nAChRs), likely displaying agonist activity. Aniracetam decreases anxiety in vivo in the condition fear stress test, elevated plus maze test, ａnd in social interaction tests. Additionally, this compound inhibits H2O2-induced deficits in long-term potentiation ａnd neuron viability. Aniracetam shows some clinical benefit in the enhancement of cognitive deficits associated with stroke ａnd Alzheimer’s disease.

Product Info

Cas No. 72432-10-1

Purity ≥98%

Formula C12H13NO3

Formula Wt. 219.24

Chemical Name 1-(4-Methoxybenzoyl)-2-pyrrolidi

IUPAC Name 1-(4-methoxybenzoyl)pyrrolidin-2-one

Synonym Ro-13-5057, Draganon, Sarpul  

Melting Point 121-122°C

Solubility Soluble in chloroform ａnd ethyl acetate. Slightly soluble in ethanol. Insoluble in water.

Appearance White or almost White Crystalline Powder

艾美捷Aniracetam #LKT-A5326-25mg是一种促智安帕因， 表现出抗焦虑和神经保护活性.阿尼西坦作为AMPA受体的正变构调节剂，减缓受体失活;它还作用于 D2 受体、5-HT2A 受体和烟碱乙酰胆碱受体 （nAChRs），可能显示激动剂活性。Aniracetam在恐惧压力测试，升高加迷宫测试和社会互动测试中减少体内焦虑。此外，该化合物抑制 H2O2 诱导的长期增强和神经元活力缺陷.阿尼西坦在增强与中风和阿尔茨海默病相关的认知缺陷方面显示出一些临床益处。

Aniracetam 参数说明：

cas#：72432-10-1

纯度：≥98%

公式： C12H13NO3

配方重量：219.24

化学名称：1-（4-甲氧基苯甲酰基）-2-吡咯烷酮

IUPAC名称：1-（4-甲氧基苯甲酰基）吡咯烷-2-酮

同义词：Ro-13-5057， 德拉加农， 萨普尔

熔点：121-122°C

溶解度：溶于氯丨仿和乙酸乙酯。微溶于乙醇。不溶于水。

外观：白色或几乎白色结晶粉末

Aniracetam文献参考：

Wang YF, Li CC, Cai JX. Aniracetam attenuates H2O2-induced deficiency of neuron viability, mitochondria potential ａnd hippocampal long-term potentiation of mice in vitro. Neurosci Bull. 2006 Sep;22(5):274-80. PMID: 17690727.

Jin R, Clark S, Weeks AM, et al. Mechanism of positive allosteric modulators acting on AMPA receptors. J Neurosci. 2005 Sep 28;25(39):9027-36. PMID: 16192394.

Nakamura K. Aniracetam: its novel therapeutic potential in cerebral dysfunctional disorders based on recent pharmacological discoveries. CNS Drug Rev. 2002 Spring;8(1):70-89. PMID: 12070527.

Nakamura K, Kurasawa M. Anxiolytic effects of aniracetam in three different mouse models of anxiety ａnd the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43. PMID: 11412837.

Ito I, Tanabe S, Kohda A, et al. Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. J Physiol. 1990 May;424:533-43. PMID: 1975272.

来源：https://lktlabs.com/product/aniracetam