艾美捷人因子Ⅻ参数说明和文献参考

XIIa的抑制剂包括 C1-INH、α2-抗纤溶酶、α2-巨球蛋白和抗凝血酶 III。在生理浓度下，这些抑制剂的相对有效性分别为 91 : 4.5 : 3 : 1.5。 C1-INH与XII的比例与因子VII的“冷激活”和血浆储存过程中肾素原向肾素的转化有关。人因子 XII是通过免疫亲和层析从新鲜冷冻血浆中制备的，并以50%（体积/体积）甘油/水的形式提供，可在-20℃下储存。

艾美捷人因子Ⅻ HCXII-0155相关参数：

Localization: 等离子

血浆浓度：40µg/ml（3）

作用方式：Zymogen；丝氨酸蛋白酶因子XIIa的体；

激肽释放酶/HMWK/阴离子表面复合物激活

阐明内在途径

分子量：80000（2）

消光系数：E1 cm，280 nm=14.0

等电点：6.8

结构：单链（Mr=80000），基于6个域组织

关于序列同源性（5）

碳水化合物百分比：17%

Localization: Plasma

Plasma concentration: 40 µg/ml (3)

Mode of action: Zymogen; precursor to the serine protease factor XIIa;

activated by kallikrein/HMWK/anionic surface complex to

intitiate the intrinsic pathway

Molecular weight: 80,000 (2)

Extinction coefficient: E1 cm, 280 nm = 14.0

Isoelectric point: 6.8

Structure: single chain (Mr = 80,000), organized into 6 domains based

on sequence homology (5)

Percent carbohydrate: 17%

人因子Ⅻ HCXII-0155文献参考：

1. Schmaier, A.H., et al., in Hemostasis ａnd Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder and

E.W. Salzman, pp 18-38, J.B. Lippincott Company, Philadelphia, 1987.

2. Griffin, J.H. ａnd Cochrane, C.G., Methods Enzymol., 45, 56-65 (1976).

3. Saito, H., et al., J Lab Clin., 88, 506 (1976).

4. McMullen, B.A. ａnd Fujikawa, N., J. Biol. Chem., 260, 5328 (1985).

5. Davie, E.W., in Hemostasis ａnd Thrombosis, ed. R.W. Colman, J. Hirsh, V.J. Marder ａnd E.W.

Salzman, pp 242-267, J.B. Lippincott Company, Philadelphia, 1987.

6. Griffin, J.H., Proc. Natl. Acad. Sci. USA, 75, 1998 (1978).

7. McMillin, L.R., et al., J. Clin. Invest., 54, 1312 (1974).

8. Revak, S.D., et al., J. Clin. Invest., 59, 1167 (1977).

9. Fujikawa, K., et al., Biochemistry, 16, 4182 (1977).

10. Bonno, N., et al., in New Comprehensive Biochemistry, ed. R.F.A. Zwaal ａnd H.C.Hemker,

pp. 103-128, Elsevier, Amsterdam, 1986.

11. Claeys, H. ａnd Collen, D. (1978) Eur. J. Biochem., 87, 69 (1978).

12. Revak, S.D. ａnd Cochrane, C.G., J. Clin. Invest., 57, 852 (1976).

13. Cochrane, C.G., et al., J. Exp. Med., 138, 1564 (1973).

14. Revak, S.D., et al., J. Exp. Med., 147, 719 (1978).

15. Ghebrehiwet, B., et al., J. Clin. Invest., 71, 1458 (1983).

16. DeAgostini, A., et al., J. Clin. Invest., 73, 1542 (1984).

17. Rathoff, O.D., et al., J. Exp. Med., 129, 315 (1969).

18. Stead, N., et al., J. Biol Chem., 251, 6481 (1976).

19. Pixley, R.A., et al., J. Biol Chem., 260, 1723 (1985).

20. Gjonnass, H., Thromb. Diath. Haemorrh., 28, 182 (1972).

21. Radcliffe, R., et al., Blood, 59, 611 (1977).

来源：https://www.amyjet.com/products/HCXII-0155.shtml