标题DDIT3 Antibody (Ascites)

WB~~1:500~1600":

CHOP
CHOP10
GADD153

DDIT3
CHOP
CHOP10
GADD153
DNA damage-inducible transcript 3 protein
C/EBP-homologous protein
C/EBP-homologous protein 10
Growth arrest ａnd DNA damage-inducible protein GADD153

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses ａnd induces cell cycle arrest ａnd apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function ａnd as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, ａnd inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM ａnd ERO1L. Negatively regulates; expression of BCL2 ａnd MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) ａnd CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties ａnd repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) ａnd both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response

WB~~1:500~1600":