标题PPARγ Antibody (H-100) AC

提供者：上海笃玛生物科技有限公司发布时间：2024/8/15 阅读次数：14次 >>进入该公司展台

Product Name	PPARγ Antibody (H-100) AC
Antibody Type	Primary Antibodies
Modification Notes	Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor subfamily of transcription factors. PPARs form heterodimers with retinoid X receptors (RXRs). These heterodimers regulate transcription of genes involved in insulin action, adipocyte differentiation, lipid metabolism ａnd inflammation. PPAR© is implicated in numerous diseases including obesity, diabetes, atherosclerosis ａnd cancer. PPAR© activators include prostanoids, fatty acids, thiazolidinediones ａnd N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation ａnd fat-specific gene expression, PPAR© may modulate macrophage functions such as proinflammatory activities, ａnd stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR©2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL ａnd be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR©2 gene maybe correlated with abdominal obesity in type 2 diabetes.

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	WBIPIFELISAGSChIP
	recommended for detection of PPARγ1 ａnd PPARγ2 of mouse, rat ａnd human origin by WB, IP, IF ａnd ELISA; also reactive with additional species, including equine, canine ａnd porcine:
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Affinity purified

Alternative Names	epie corresponding to amino acids 8-106 mapping at the N-terminus of PPAR&gamma 1 of human origin
Tissue Specificity	epie corresponding to amino acids 8-106 mapping at the N-terminus of PPARγ1 of human origin

Entrez Gene	5468

Application

Western blot analysis of PPARγ expression in U-937 whole cell lysate.
Application

Western blot analysis of PPARγ expression in non-transfected 293T: (A), human PPARγ transfected 293T: (B) ａnd THP-1 (C) whole cell lysates.
Application

Western blot analysis of human recombinant PPARγ.
Application

Western blot analysis of PPARγ expression in non-transfected: (A) ａnd mouse PPARγ transfected: (B) 293T whole cell lysates.
Application

Western blot analysis of PPARγ expression in non-transfected: (A) ａnd human PPARγ transfected: (B) 293T whole cell lysates.
Application

Western blot analysis of PPARγ expression in THP-1 (A) ａnd 3T3-L1 (B) whole cell lysates.
Application

Western blot analysis of human recombinant PPARγ fusion protein.

Application Notes	recommended for detection of PPARγ1 ａnd PPARγ2 of mouse, rat ａnd human origin by WB, IP, IF ａnd ELISA; also reactive with additional species, including equine, canine ａnd porcine:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

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