标题Caspase 9 (phospho Thr125) antibody

Rabbit Polyclonal antibody to Caspase 9 (phospho Thr125)This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large ａnd small, that dimerize to form the active enzyme. This protein can undergo auroteolytic processing ａnd activation by the apoptosome, a protein complex of cytochrome c ａnd the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis ａnd to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
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Peptide sequence around phosphorylation site of threonine 125 (P-E-T(p)-P-R) derived from Human Caspase 9.

IHC-PWB

Human