标题Occludin antibody Catalog Number：OM266244

Rabbit Polyclonal antibody to OccludinTight junctions act as a semi-permeable barrier to the transport of ions, solutes, ａnd water ａnd are considered to function as a fence that divides apical ａnd basolateral domains of plasma membranes. Tight junctions coordinate a variety of signaling ａnd trafficking molecules regulating cell differentiation, proliferation, ａnd polarity ａnd contain a number of junctional proteins including Occludin, Claudins, junctional adhesion molecules (JAMs), as well as multiple scaffold proteins. Occludin, the first identified component of tight junction strands, is thought function as a signal transmitter in multiple signaling pathways ａnd can associate with multiple kinases ａnd phosphatases such as PI3-kinase ａnd protein phosphatases 1 ａnd 2A. At least two isoforms of OCLN are known to exist.
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The immunogen corresponding to a region within amino acids 472 ａnd 522 of human OCLN.

WB

HumanMouseRat