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| Product Name | Anti-Cleaved-Caspase 3 (Asp175) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFWB |
| WB:1:200-1:2000 ICC/IF:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1 mg/ml |
| Purification | Protein A |
| Gene Symbol | CASP3 |
|---|---|
| Gene Synonyms | |
| Gene Full Name | caspase 3 |
| Gene Summary | The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves ａnd inactivates poly(ADP-ribose) polymerase while it cleaves ａnd activates sterol regulatory element binding proteins as well as caspases 6, 7, ａnd 9. This protein itself is processed by caspases 8, 9, ａnd 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer＇s disease. [provided by RefSeq, Aug 2017] Hide |
| Molecular Weight(MW) | 17 KDa |
| Cellular Localization | Cylasm |
Western blot analysis using Cleaved-Caspase 3 antibody against HepG2 (1) cell lysate.
Immunofluorescence analysis of T24 cells using Cleaved-Caspase 3 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | WB:1:200-1:2000 ICC/IF:1:100-1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
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