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您的位置：首页 > 技术文献 > 产品说明 > Nrf2 Catalog Number：OM638791

标题Nrf2 Catalog Number：OM638791

提供者：上海笃玛生物科技有限公司发布时间：2024/8/19 阅读次数：7次 >>进入该公司展台

Product Profile

Product Name	Nrf2
Antibody Type	Primary Antibodies
Product description	The Nrf2 antioxidant response pathway is "the primary cellular defense against the cytotoxic effects of oxidative stress." Among other effects, NFE2L2 increases the expression of several antioxidant enzymes. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress, ａnd dimethyl fumarate significantly reduced the progression of disability in multiple sclerosis. Under normal or unstressed conditions, Nrf2 is kept in the cylasm by a cluster of proteins that degrade it quickly. Under oxidative stress, Nrf2 is not degraded, but instead travels to the nucleus where it binds to a DNA promoter ａnd initiates transcription of antioxidative genes ａnd their proteins. More
Immunogen	This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to Nrf2 aa 530-600.

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	WBICC
	WB:1:1000-1:2000 ICC:1:100
Species Reactivity	HumanMouseRat
Concentration	1 mg/mL.

Target Information

Alternative Names	erythroid derived 2 antibody HEBP1 antibody like 2 antibody NF E2 related factor 2 antibody NF-E2-related factor 2 antibody NF2L2_HUMAN antibody NFE2 related factor 2 antibody NFE2-related factor 2 antibody Nfe2l2 antibody Nrf 2 antibody NRF2 antibody Nuclear factor (erythroid derived 2) like 2 antibody Nuclear factor antibody nuclear factor erythroid 2 like 2 antibody Nuclear factor erythroid 2 related factor 2 antibody Nuclear factor erythroid 2-related factor 2 antibody Nuclear factor erythroid derived 2 like 2 antibody Hide
Molecular Weight(MW)	68 kDa
Cellular Localization	Cylasm, Nucleus

Database Links

SwissProt ID	Q16236

Application

Application

Fig1: Western blot analysis on different lysates using anti-Nrf2 rabbit polyclonal antibodies.
Application

Fig2: ICC staining Nrf2 in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Positive Control	Raji, mouse liver, HepG2, Hela
Application Notes	WB:1:1000-1:2000 ICC:1:100

Additional Information

Form	Liquid
Storage Instructions	Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage Buffer	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

关键词：稳定性强特异性强灵敏度高

上一篇：Nrf2 Antibody Catalog Number：OM215667 下一篇：Phospho-Nrf2(S40) [SU0334] Catalog Number：OM637230

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