标题NFE2L2-Y576 Antibody Catalog Number：OM215278

提供者：上海笃玛生物科技有限公司发布时间：2024/8/19 阅读次数：32次 >>进入该公司展台

Product Name	NFE2L2-Y576 Antibody
Antibody Type	Primary Antibodies

Gene Synonyms	NRF2
Alternative Names	NFE2L2 NRF2 Nuclear factor erythroid 2-related factor 2 HEBP1 Nuclear factor erythroid derived 2 like 2 Hide
Molecular Weight(MW)	67827 Da
Function	Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region Hide
Tissue Specificity	Widely expressed. Highest expression in adult muscle, kidney, lung, liver ａnd in fetal muscle
Cellular Localization	Cylasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents

Entrez Gene	4780
Nucleotide Accession	NP_006155

Application

Western blot analysis of Phospho-NFE2L2-Y576 in Jurkat cell line lysates (35ug/lane). NFE2L2 (arrow) was detected using the purified Pab.
Application

Formalin-fixed ａnd paraffin-embedded human lung carcinoma reacted with NFE2L2-Y576 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Application

NFE2L2-Y576 Antibody flow cytometric analysis of NCI-H460 cells (bottom histogram) compared to a negative control cell ( histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Application Notes	WB~~1:100~500 IHC~~1:50~100 FC~~1:10~50:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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