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| Product Name | Rabbit anti-TLR4 polyclonal antibody - middle region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-TLR4 antibody: synthetic peptide directed towards the middle region of human TLR4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHCWB |
| WB:1:500~1:2000 IHC:1:50~1:200 ICC/IF:1:50~1:200 | |
| Species Reactivity | HumanPig |
| Concentration | 1 mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TLR4 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | Toll-like receptor 4 |
| Gene Summary | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition ａnd activation of innate immunity. TLRs are highly conserved from Drosophila to humans ａnd share structural ａnd functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, ａnd mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, ａnd in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. More |
| Alternative Names | More |
| Molecular Weight(MW) | 93kDa |
| Sequence | 839 amino acids |
| Entrez Gene | 7099 |
|---|---|
| SwissProt ID | O00206 |
| Protein Accession | NP_612564 |
Sample Type: Human Macrophange Cells
Green: primary
Red: phallodin
Blue: DAPI
Yellow: green/red
Primary Dilution: 1:200
Secondary Antibody: anti-Rabbit IgG-FITC
Secondary Dilution: 1:1000
Image Submitted By: Milan Fiala
University of California, Los Angeles
| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 ICC/IF:1:50~1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot ａnd store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol. |
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