标题Anti-TLR4 antibody Catalog Number：OM641714

IHC:1:200-1:1000

TOLL
CD284
TLR-4
ARMD10

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition ａnd activation of innate immunity. TLRs are highly conserved from Drosophila to humans ａnd share structural ａnd functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, ａnd mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, ａnd with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

IHC:1:200-1:1000