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| Product Name | Anti-ZO 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHCWB |
| WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1 mg/ml |
| Purification | Protein A |
| Gene Symbol | TJP1 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | tight junction protein 1 |
| Gene Summary | This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, ａnd acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions ａnd macromolecules between endothelial ａnd epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain ａnd unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, ａnd F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] More |
| Molecular Weight(MW) | 195 kDa |
| Source | Rabbit |
| Cellular Localization | Cell junction; Cell membrane; Cell projection; Gap junction; Membrane; Tight junction |
Western blot analysis using ZO 1 antibody against A431 (1) cell lysate.
Immunohistochemical analysis of paraffin-em
Immunofluorescence analysis of A431 cells using ZO 1 (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | WB:1:200-1:2000 IHC:1:200-1:1000 ICC/IF:1:100-1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
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