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| Product Name | Anti-Interleukin 1 beta antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHCWB |
| WB:1:500-1:2000 IHC:1:200-1:1000 ICC:1:50-1:200 | |
| Species Reactivity | HumanMouseRabbit |
| Concentration | 1.0mg/ml |
| Purification | Protein A |
| Gene Symbol | IL1B |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | interleukin 1 beta |
| Gene Summary | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, ａnd is involved in a variety of cellular activities, including cell proliferation, differentiation, ａnd apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene ａnd eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] More |
| Molecular Weight(MW) | 31kDa |
| Cellular Localization | Cylasm>Cytosol. Lysosome. Secreted>Extracellular exosome. Secreted. |
Figure 1: Western blot analysis using Interleukin 1 beta antibody against Mcf-7(1) cell lysate.
Figure 2: Immunohistochemical analysis of paraffin-em
Figure 3: Immunofluorescence analysis of A549 cells using Interleukin 1 beta antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | WB:1:500-1:2000 IHC:1:200-1:1000 ICC:1:50-1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300. |
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