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Product Name | Anti-Interleukin 1 beta antibody |
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Antibody Type | Primary Antibodies |
Immunogen | Polypeptide |
Clonality | Polyclonal |
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Isotype | IgG |
Host Species | Human |
Tested Applications | ELISAIHCWB |
WB:1:200-1:2000 IHC:1:200-1:1000 | |
Species Reactivity | GoatHumanMouseRat |
Concentration | 1.0mg/ml |
Purification | Protein A |
Gene Symbol | IL1B interleukin 1 beta |
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Gene Synonyms | More |
Gene Full Name | interleukin 1 beta |
Gene Summary | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020] More |
Molecular Weight(MW) | 31 kDa |
Source | Rabbit |
Cellular Localization | Cylasm>Cytosol. Lysosome. Secreted>Extracellular exosome. Secreted. |
Western blot analysis using Interleukin 1 beta antibody against NIH 3T3 (1), K562 (2) cell lysate.
Immunohistochemical analysis of paraffin-em
Application Notes | WB:1:200-1:2000 IHC:1:200-1:1000 |
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Form | Liquid |
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Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
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