标题BRCA1 Antibody Catalog Number：OM272678

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination ａnd transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase ａnd the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA ａnd preventing its dephosphorylation1) Lin SY, et al. (2004) Proc Natl Acad Sci U S A, 101 (17): 6484-6489Zhang J, et al. (2004) Mol Cell Biol; 24 (2): 708-718Beger C, et al. (2001) Proc Natl Acad Sci U S A; 98 (1): 130-135Gardner K, et al. (2001) Breast Cancer Res; 3 (1): 11-13Zheng L, et al. (2001) Proc Natl Acad Sci U S A; 98 (17): 9587-9592
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BRCA1 (Ab-1524) antibody was raised against a peptide sequence around aa.1522~1526 (Y-P-S-Q-E) derived from Human BRCA1.

IFWB

Human