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您的位置：首页 > 技术文献 > 产品说明 > BRCA1 antibody Catalog Number：OM241906

标题BRCA1 antibody Catalog Number：OM241906

提供者：上海笃玛生物科技有限公司发布时间：2024/8/23 阅读次数：41次 >>进入该公司展台

Product Profile

Product Name	BRCA1 antibody
Antibody Type	Primary Antibodies
Product description	Rabbit Polyclonal antibody to BRCA1The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination ａnd transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase ａnd the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA ａnd preventing its dephosphorylation More
Immunogen	Peptide sequence around aa.1421~1425 (H-G-S-Q-P) derived from Human BRCA1.

Key Feature

Clonality	Polyclonal
Host Species	Rabbit
Tested Applications	IHC-PWB
	Suggested starting dilutions are as follows. WB: 1:500~1:1000, IHC-P: 1:50~1:100, ICC/IF: . Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration)
Purification	Affinity purified

Target Information

Gene Synonyms	BRCAI BRCC1 BROVCA1 IRIS PNCA4 PSCP RNF53 BRCA1 breast cancer type 1 susceptibility protein RING finger protein 53 breast ａnd ovarian cancer sususceptibility protein 1 breast ａnd ovarian cancer susceptibility protein 1 protein phosphatase 1 re More
Target	BRCA1
Molecular Weight(MW)	220 (note)

Application

Application

Western blot analysis of extracts from Hela ａnd HT29 cells using BRCA1(Ab-1423) Antibody
Application

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BRCA1 Antibody (left) or the same antibody preincubated with blocking peptide (right).
Application

Western blot analysis of extracts from Hela ａnd HT29 cells using BRCA1 Antibody .

Application Notes	Suggested starting dilutions are as follows. WB: 1:500~1:1000, IHC-P: 1:50~1:100, ICC/IF: . Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:

Additional Information

Form	Liquid
Storage Instructions	Keep as concentrated solution. Aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	saline (without Mg2+ ａnd Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

关键词：稳定性强特异性强灵敏度高

上一篇：BRCA1 antibody - ChIP grade Catalog Number：OM241911 下一篇：BRCA1 (phospho Ser988) antibody Catalog Number：OM241905

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