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您的位置：首页 > 技术文献 > 产品说明 > FLT3 antibody Catalog Number：OM253326

标题FLT3 antibody Catalog Number：OM253326

提供者：上海笃玛生物科技有限公司发布时间：2024/8/26 阅读次数：15次 >>进入该公司展台

Product Profile

Product Name	FLT3 antibody
Antibody Type	Primary Antibodies
Product description	Rabbit Polyclonal antibody to FLT3FLT3 encodes a class III receptor tyrosine kinase that regulates hemaoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, ａnd a cylasmic kinase domain split into two parts by a kinase-ｉnsert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to auhosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates ａnd activates multiple cylasmic effector molecules in pathways involved in apoptosis, proliferation, ａnd differentiation of hemaoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia ａnd acute lymphoblastic leukemia. More
Immunogen	Peptide sequence around aa.589~593 (Y-F-Y-V-D) derived from Human FLT3.

Key Feature

Clonality	Polyclonal
Host Species	Rabbit
Tested Applications	ICC/IFWB
	Suggested starting dilutions are as follows. WB: 1:500~1:1000, ICC/IF: 1:100~1:200. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Species Reactivity	Human
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration)
Purification	Affinity purified

Target Information

Gene Synonyms	CD135 FLK2 STK1 FLT3 FLT3 receptor tyrosine kinase STK-1 FLT-3 CD135 antigen fetal liver kinase-2 stem cell tyrosine kinase 1 tyrosine-protein kinase receptor FLT3 growth factor receptor tyrosine kinase type III fms-like tyrosine kinase 3 FL c More
Target	FLT3
Molecular Weight(MW)	130, 160 (note)

Application

Application

Western blot analysis of extracts from 293 ａnd MCF cells using FLT3 Antibody .
Application

Immunofluorescence staining of methanol-fixed Hela cells using FLT3 Antibody .

Application Notes	Suggested starting dilutions are as follows. WB: 1:500~1:1000, ICC/IF: 1:100~1:200. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:

Additional Information

Form	Liquid
Storage Instructions	Keep as concentrated solution. Aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	saline (without Mg2+ ａnd Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

关键词：稳定性强特异性强灵敏度高

上一篇：FLT3 Antibody Catalog Number：OM278969 下一篇：Rabbit anti-FLT3 (Phospho-Tyr969) polyclonal antibody Catalog Number：OM123944

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