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您的位置：首页 > 技术文献 > 产品说明 > FLT3 [C3-B7] Catalog Number：OM627668

标题FLT3 [C3-B7] Catalog Number：OM627668

提供者：上海笃玛生物科技有限公司发布时间：2024/8/26 阅读次数：16次 >>进入该公司展台

Product Profile

Product Name	FLT3 [C3-B7]
Antibody Type	Primary Antibodies
Product description	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG ａnd regulates differentiation, proliferation ａnd survival of hemaoietic progenitor cells ａnd of dendritic cells. Promotes phosphorylation of SHC1 ａnd AKT1, ａnd activation of the downstream effector MTOR. Promotes activation of RAS signaling ａnd phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, ａnd STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation ａnd resistance to apoptosis via the activation of multiple signaling pathways. More
Immunogen	Recombinant protein

Key Feature

Clonality	Monoclonal
Isotype	IgG1
Host Species	Mouse
Tested Applications	WBIHC
	WB:1:250~1:1000 IHC:1:20~1:100 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity	Human
Concentration	2 mg/mL.

Target Information

Alternative Names	CD 135 antibody CD135 antibody CD135 antigen antibody Fetal liver kinase 2 antibody FL cytokine receptor antibody Flk 2 antibody Flk2 antibody Flt 3 antibody FLT-3 antibody Flt3 antibody FLT3_HUMAN antibody FMS like tyrosine kinase 3 antibody Fms related tyrosine kinase 3 antibody Fms-like tyrosine kinase 3 antibody Growth factor receptor tyrosine kinase type III antibody Ly-72 antibody OTTHUMP0000004234 antibody Receptor type tyrosine protein kinase FLT3 antibody Stem cell tyrosine kinase 1 antibody Stk 1 antibody STK-1 antibody Stk1 antibody Tyrosine protein kinase receptor FLT3 antibody Tyrosine-protein kinase receptor FLT3 antibody More
Molecular Weight(MW)	113 kDa
Cellular Localization	Endoplasmic reticulum lumen, membrane.

Database Links

SwissProt ID	P36888

Application

Application

Fig1: Western blot analysis of FLT3 on human FLT3 recombinant protein using anti-FLT3 antibody at 1/1,000 dilution.
Application

Fig2: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-FLT3 antibody. Counter stained with hematoxylin.
Application

Fig3: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-FLT3 antibody. Counter stained with hematoxylin.

Positive Control	Human FLT3 recombinant protein, FLT3-hIgGFc transfected HEK293 cell lysate, human cervical cancer tissue. human liver cancer tissue.
Application Notes	WB:1:250~1:1000 IHC:1:20~1:100 Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form	Liquid
Storage Instructions	Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer	1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.

关键词：稳定性强特异性强灵敏度高

上一篇：Rabbit anti-Flt3 ligand polyclonal antibody Catalog Number：OM123946 下一篇：FLT3 antibody Catalog Number：OM253330

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